{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:43:01Z","timestamp":1793194981317,"version":"4.5.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recent studies have suggested a link between reproductive health and later-life chronic conditions, yet the mechanism remains unclear. One proposed mechanism is through chronic inflammation. The objective of this study was to examine the association between endometriosis and uterine fibroids and biomarkers of inflammation and cellular aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      We used data from the National Health and Nutrition Examination Survey (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u20092342; 1999\u20132002). Adjusted logistic and linear regression were used to examine the association between these two reproductive conditions and elevated C-reactive protein (CRP; &gt;3.0\u2009mg\/L) and leukocyte telomere length (T\/S ratio), respectively. Given that a greater length of time spent with a condition may represent persistence of an inflammatory process, we further examined the association between time since disease diagnosis on telomere length among the subset of women with diagnosed endometriosis and fibroids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Women with endometriosis had greater odds of having elevated CRP than those without endometriosis (OR\u2009=\u20091.60; 95% CI: 1.05 to 2.45). Women with endometriosis had a shorter telomere length than women without endometriosis (\u22123.4, 95% CI: \u22127.3 to \u22120.3 in age-adjusted models and \u22122.9, 95% CI: \u22128.8 to 3.5 in fully adjusted models). Telomeres were 1% (95% CI: \u22121.2 to \u22120.6) shorter for every elapsed year since endometriosis diagnosis. No substantive patterns emerged between uterine fibroids and CRP or telomere length.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Women with endometriosis (or a longer duration of time spent with endometriosis) had higher inflammatory markers and shorter mean telomere length. These results provide further insights into potential mechanisms linking endometriosis to chronic disease and later-life health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0044","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T12:03:33Z","timestamp":1630065813000},"page":"1020-1028","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Endometriosis and Uterine Fibroids and Their Associations with Elevated C-Reactive Protein and Leukocyte Telomere Length Among a Representative Sample of U.S. Women: Data from the National Health and Nutrition Examination Survey, 1999\u20132002"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-7931","authenticated-orcid":false,"given":"Jessica L.","family":"Gleason","sequence":"first","affiliation":[{"name":"Maternal &amp; Child Health Program, Department of Family Science, School of Public Health, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Maternal &amp; Child Health Program, Department of Family Science, School of Public Health, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Zukerman Willinger","sequence":"additional","affiliation":[{"name":"Maternal &amp; Child Health Program, Department of Family Science, School of Public Health, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond D.","family":"Shenassa","sequence":"additional","affiliation":[{"name":"Maternal &amp; Child Health Program, Department of Family Science, School of Public Health, University of Maryland, College Park, Maryland, USA."},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, Maryland, USA."},{"name":"Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA."},{"name":"Department of Epidemiology &amp; 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