{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:54:14Z","timestamp":1790949254819,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Many women with endometriosis experience chronic abdominal pain. Clinical guidelines recommend treatment with analgesics, contraceptive hormones, gonadotropin-releasing hormone analogs, and surgery. Treatment patterns in women with endometriosis are not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data from the IBM\n                      <jats:sup>\u00ae<\/jats:sup>\n                      MarketScan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Commercial Database were accessed from 2009 to 2017. One-year baseline and follow-up periods were defined around the date of the first claim with a diagnosis of endometriosis (the index date). Women 18\u201349 years of age on the index date with a diagnosis of endometriosis, continuous enrollment during baseline and follow-up, and pharmacy benefits were included. The following outcomes were analyzed descriptively: baseline comorbidities; medication use and surgeries; and sequence of treatment utilization in the baseline and the follow-up period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 190,921 women were included. The mean\u2009\u00b1\u2009(standard deviation) age was 39.0\u2009\u00b1\u2009(7.3), and abdominal\/pelvic pain (36.0%) and excessive or frequent menstruation (32.0%) were the most prevalent comorbidities. In the baseline period, the utilization of pharmacological treatment was: estrogen\/progestin 42.5%, opioids 41.5%, and nonsteroidal anti-inflammatory drugs (NSAIDs) 37.5%. In the follow-up period, utilization of opioids and NSAIDs increased to 68.9% and 51.1%, respectively, whereas the use of estrogen\/progestin dropped to 23.8%. Surgeries were infrequent in the baseline period (6.3%). However, in the follow-up period, 27.9% of women underwent laparoscopy and 29.7% had a hysterectomy, with a total of 68.1% of the study population undergoing surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A diagnosis of endometriosis is accompanied by an increase in the use of analgesics and surgical procedures. The diversity of treatments suggests a lack of clarity in management guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0060","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T14:22:18Z","timestamp":1638282138000},"page":"1003-1011","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Surgical and Pharmacological Treatment Patterns in Women with Endometriosis: A Descriptive Analysis of Insurance Claims"],"prefix":"10.1177","volume":"31","author":[{"given":"Jessica","family":"Weaver","sequence":"first","affiliation":[{"name":"Merck &amp; Co., Inc., Kenilworth, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-5135","authenticated-orcid":false,"given":"Sreya","family":"Chakladar","sequence":"additional","affiliation":[{"name":"Complete HEOR Solutions, North Wales, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Mirchandani","sequence":"additional","affiliation":[{"name":"Complete HEOR Solutions, North Wales, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc., Kenilworth, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.66699"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.12.039"},{"key":"e_1_3_5_5_2","first-page":"594","article-title":"Diagnosis and management of endometriosis","volume":"74","author":"Mounsey AL","year":"2006","unstructured":"Mounsey AL, , Wilgus A, , Slawson DC. 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Health care utilization and costs associated with endometriosis among women with Medicaid Insurance. J Manag Care Spec Pharm, 2019; 25:566\u2013572.","journal-title":"J Manag Care Spec Pharm"},{"key":"e_1_3_5_14_2","first-page":"174550652096589","article-title":"The impact of high-risk and chronic opioid use among commercially insured endometriosis patients on health care resource utilization and costs in the United States","volume":"16","author":"Estes SJ","year":"2020","unstructured":"Estes SJ, , Soliman AM, , Zivkovic M, , Chopra D, , Zhu X. The impact of high-risk and chronic opioid use among commercially insured endometriosis patients on health care resource utilization and costs in the United States. 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