{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:45:30Z","timestamp":1777916730293,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Vaginal\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      is considered protective of some adverse reproductive health outcomes, including preterm birth. However, factors that increase or decrease the likelihood of harboring\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      in the vaginal microbiome remain largely unknown. In this study, we sought to identify risk and protective factors associated with vaginal\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      predominance within a cohort of pregnant African American women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Vaginal microbiome samples were self-collected by African American women (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u2009436) during their 8\u201314th week of pregnancy. Sociodemographic information and measures of health behaviors, including substance use, antibiotic exposure, sexual practices, frequency of vaginal intercourse, and the use of vaginal products, were collected through participant self-report. The V3\u2013V4 region of the 16S rRNA gene was targeted for amplification and sequencing using Illumina HiSeq, with bacterial taxonomy assigned using the PECAN classifier. Univariate and a series of multivariate logistic regression models identified factors predictive of diverse vaginal microbiota or\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      predominance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Participants who used marijuana in the past 30 days (aOR 1.80, 95% CI 1.08\u20132.98) were more likely to have diverse non-\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      -predominant vaginal microbiota, as were women not living with their partners (aOR 1.90, 95% CI 1.20\u20133.01). Cohabitating or marijuana usage were not associated with type of\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      (non-\n                      <jats:italic toggle=\"yes\">iners Lactobacillus<\/jats:italic>\n                      vs.\n                      <jats:italic toggle=\"yes\">Lactobacillus iners<\/jats:italic>\n                      ) predominance (aOR 1.11, 95% CI 0.52\u20132.38 and aOR 0.56, 95% CI 0.21\u20131.47, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Living with a partner is conducive to vaginal\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      predominance. As such, cohabitation may be in important covariate to consider in vaginal microbiome studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0148","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T11:59:14Z","timestamp":1630065554000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors Associated with Vaginal\n                    <i>Lactobacillus<\/i>\n                    Predominance Among African American Women Early in Pregnancy"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-8740","authenticated-orcid":false,"given":"Michelle L.","family":"Wright","sequence":"first","affiliation":[{"name":"School of Nursing, The University of Texas at Austin, Austin, Texas, USA."},{"name":"Department of Women's Health, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne L.","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis B.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA."},{"name":"Department of Computer Science, College of Arts and Sciences, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily F.","family":"Wissel","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Corwin","sequence":"additional","affiliation":[{"name":"School of Nursing, Columbia University, New York, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.081034-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-4"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.05.030"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00410-17"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705899114"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00181"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1099800420940788"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0450-2"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.641005"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.02.020"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.864"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318211726f"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828786f8"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1745505717731011"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.11.007"},{"key":"e_1_3_5_18_2","first-page":"1303265","article-title":"Changes in vaginal community state types reflect major shifts in the microbiome","volume":"28","author":"Brooks JP","year":"2017","unstructured":"Brooks JP, , Buck GA, , Chen G, et al. 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