{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:06:29Z","timestamp":1788444389224,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Women worldwide face risks from pregnancy, HIV, and other sexually transmitted infections (STIs). To date, highly effective contraceptive methods provide no HIV\/STI protection, and HIV prevention products, excluding condoms, provide no pregnancy protection. Intravaginal rings (IVRs) delivering antiretrovirals and contraceptives are a promising multipurpose prevention technology (MPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Embedded within a Phase I randomized, placebo-controlled trial, we examined acceptability of continuous versus interrupted use of a 90-day MPT IVR among 47 low-risk women in Norfolk, Virginia and the Dominican Republic. A baseline survey assessed menstruation attitudes, risk perceptions and trial-related motivations. Follow-up surveys (M1\/M3) examined user experiences with and preferences for IVR attributes; 18 women also participated in two in-depth interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Most women rated the IVR's flexibility and smoothness (86%) and ease of insertion\/removal (76%) as very acceptable. Fewer women similarly rated the IVR size (57%) and changes in color from menstruation (52%). Most participants experienced no changes or less bleeding. Those reporting more\/heavier bleeding (20% M1, 15% M3) disliked the change. Overall, women preferred a 3-month (75%) to a 1-month IVR (7.5%) or a bimonthly injectable (10%). In qualitative interviews, women were willing to continuously use an IVR for 6\u201312 months, providing it did not \u201c\n                      <jats:italic toggle=\"yes\">degrade<\/jats:italic>\n                      \u201d inside the body. Reasons for trial participation and prevention preferences, menstrual attitudes, and perceived IVR benefits and doubts varied by site.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Findings provide strong evidence of demand for an MPT IVR that protects from pregnancy and HIV\/STIs, lasts longer than 1 month, minimally disrupts menstrual bleeding, and is in women's control.\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/numberClinicalTrials.gov\">numberClinicalTrials.gov<\/jats:uri>\n                      : #NCT03279120.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0394","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T13:24:01Z","timestamp":1648819441000},"page":"1343-1352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Acceptability of a Long-Acting, Multipurpose Vaginal Ring: Findings from a Phase I Trial in the U.S. and Dominican Republic"],"prefix":"10.1177","volume":"31","author":[{"given":"Elizabeth E.","family":"Tolley","sequence":"first","affiliation":[{"name":"Behavioral, Epidemiological &amp; Clinical Sciences, FHI 360, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Zissette","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health, Emory University, Department of Epidemiology (PhD Student), Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamilah","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Duke University, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homaira","family":"Hanif","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ju","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Schwarz","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Thurman","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Tyner","sequence":"additional","affiliation":[{"name":"Profamilia, Santo Domingo, Dominican Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Brache","sequence":"additional","affiliation":[{"name":"Profamilia, Santo Domingo, Dominican Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Doncel","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"1","article-title":"Sexual and reproductive health and rights are key to global development: The case for ramping up investment","volume":"18","author":"Barot S","year":"2015","unstructured":"Barot S. Sexual and reproductive health and rights are key to global development: The case for ramping up investment. Guttmacher Policy Review, 2015; 18:1\u20137.","journal-title":"Guttmacher Policy Review"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12842"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1728-4465.2010.00250.x"},{"key":"e_1_3_5_5_2","unstructured":"UN Women. New York NY: Facts and figures: HIV and AIDS 2018."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932012000715"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/padr.12051"},{"key":"e_1_3_5_8_2","first-page":"103","article-title":"Why family planning policy and practice must guarantee a true choice of contraceptive methods","volume":"20","author":"Sonfield A","year":"2017","unstructured":"Sonfield A. Why family planning policy and practice must guarantee a true choice of contraceptive methods. Guttmacher Policy Rev, 2017; 20:103\u2013107.","journal-title":"Guttmacher Policy Rev"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272684X16685254"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002215"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X17729376"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05399-4"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.08.037"},{"key":"e_1_3_5_14_2","first-page":"62","article-title":"State of the art in intravaginal ring technology for topical prophylaxis of HIV infection","volume":"14","author":"Kiser PF","year":"2012","unstructured":"Kiser PF, , Johnson TJ, , Clark JT. State of the art in intravaginal ring technology for topical prophylaxis of HIV infection. AIDS Rev, 2012; 14:62\u201377.","journal-title":"AIDS Rev"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/23294515.2016.1251506"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.06.021"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S34030"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1363\/psrh.12103"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S185712"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198009000-00005"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195499"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25283"},{"issue":"25094","key":"e_1_3_5_23_2","first-page":"1","article-title":"The Tablets, Ring, Injections as Options (TRIO) study: What young African women chose and used for future HIV and pregnancy prevention","volume":"21","author":"Van der Straten A","year":"2018","unstructured":"Van der Straten A, , Agot K, , Ahmen K, et al. The Tablets, Ring, Injections as Options (TRIO) study: What young African women chose and used for future HIV and pregnancy prevention. J Int AIDS Soc, 2018; 21(epub25094):1\u20139.","journal-title":"J Int AIDS Soc"},{"key":"e_1_3_5_24_2","unstructured":"Baeten J Palanee-Phillips T Mgodi N et al. High adherence and sustained impact on HIV-1 incidence: Final results of an open-label extension trial of the dapivirine vaginal ring. 10th IAS Conference on HIV Science; Mexico City Mexico: International AIDS Society 2019."}],"container-title":["Journal of Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jwh.2021.0394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2021.0394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2021.0394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:56:03Z","timestamp":1777658163000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jwh.2021.0394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1089\/jwh.2021.0394"],"URL":"https:\/\/doi.org\/10.1089\/jwh.2021.0394","relation":{},"ISSN":["1540-9996","1931-843X"],"issn-type":[{"value":"1540-9996","type":"print"},{"value":"1931-843X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}