{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T21:32:47Z","timestamp":1782682367422,"version":"3.54.5"},"reference-count":26,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We assessed whether general practitioner (GP) delivery of a vaginal self-sampling kit was non-inferior to home-mailed delivery on cervical cancer screening (CCS) participation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Two hundred and ten French GPs from Indre-et-Loire French department were randomized into two groups, and their unscreened women patients aged 30\u201365 were included in February\u2013March 2015. In the GP delivery group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009105 GPs; 1,806 women), women were sent a reminder letter inviting them to collect a vaginal self-sampling kit at their regular GP's practice. In the home-mailed delivery group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009105 GPs; 1,806 women), women were sent a reminder letter with a vaginal self-sampling kit directly at home. The primary outcome was participation in complete CCS within 9 months. A cost-effectiveness analysis was also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At 9 months, 14.9% (95% CI: 12.9\u201316.9) and 27.9% (95% CI: 25.7\u201330.0) of women in the GP and home-mailed delivery groups participated in complete CCS. The absolute between-group difference was \u221213.0 percentage points (95% CI: \u221215.9 to \u221210.0) in favor of the home-mailed delivery group, crossing the non-inferiority pre-defined non-inferiority margin of 5%. The home-mailed delivery strategy cost 50.81\u20ac more per additional woman screened.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">The<\/jats:italic>\n                      GP delivery was inferior to home-mailed delivery in increasing participation in CCS. Home-mailed delivery of a vaginal self-sampling kit is a cost-effective way to increase CCS in that the additional cost of this strategy seems acceptable. This study is registered at\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.Clinicaltrials.gov\">www.Clinicaltrials.gov<\/jats:uri>\n                      NCT02255084.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0597","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T14:16:22Z","timestamp":1657808182000},"page":"1472-1480","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Home-Mailed Versus General Practitioner-Delivered Vaginal Self-Sampling Kit for Cervical Cancer Screening: A Cluster Randomized Controlled Trial with a Cost-Effectiveness Analysis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-8668","authenticated-orcid":false,"given":"Julie","family":"Boyard","sequence":"first","affiliation":[{"name":"Cancer Screening Department, CHRU de Tours, Tours, France."},{"name":"\u00c9quipe d'accueil Recherche EA7505 (\u00c9ducation, \u00c9thique, Sant\u00e9), Universit\u00e9 de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-6144","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Caille","sequence":"additional","affiliation":[{"name":"INSERM CIC1415, CHRU de Tours, Tours, France."},{"name":"Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Brunet-Houdard","sequence":"additional","affiliation":[{"name":"\u00c9quipe d'accueil Recherche EA7505 (\u00c9ducation, \u00c9thique, Sant\u00e9), Universit\u00e9 de Tours, Tours, France."},{"name":"Health Economics Evaluation Unit, CHRU de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somany","family":"Sengchanh-Vidal","sequence":"additional","affiliation":[{"name":"Cancer Screening Department, CHRU de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Giraudeau","sequence":"additional","affiliation":[{"name":"INSERM CIC1415, CHRU de Tours, Tours, France."},{"name":"Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Marret","sequence":"additional","affiliation":[{"name":"PRES Centre-Val de Loire Universit\u00e9, Universit\u00e9 de Tours, Tours, France."},{"name":"Department of Gynecology and Obstetrics, CHRU de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Rolland-Lozachmeur","sequence":"additional","affiliation":[{"name":"INSERM UMR 1101, Brest, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Rusch","sequence":"additional","affiliation":[{"name":"\u00c9quipe d'accueil Recherche EA7505 (\u00c9ducation, \u00c9thique, Sant\u00e9), Universit\u00e9 de Tours, Tours, France."},{"name":"Health Economics Evaluation Unit, CHRU de Tours, Tours, France."},{"name":"PRES Centre-Val de Loire Universit\u00e9, Universit\u00e9 de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-4762","authenticated-orcid":false,"given":"Catherine","family":"Gaudy-Graffin","sequence":"additional","affiliation":[{"name":"PRES Centre-Val de Loire Universit\u00e9, Universit\u00e9 de Tours, Tours, France."},{"name":"Department of Bacteriology, Virology and Hygiene, CHRU de Tours, Tours, France."},{"name":"INSERM U1259, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haguenoer","sequence":"additional","affiliation":[{"name":"Cancer Screening Department, CHRU de Tours, Tours, France."},{"name":"\u00c9quipe d'accueil Recherche EA7505 (\u00c9ducation, \u00c9thique, Sant\u00e9), Universit\u00e9 de Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000365"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr015"},{"key":"e_1_3_7_5_2","unstructured":"French National Authority for Health. [Assessment and recommendations for cervical cancer screening in France]. Published online July 2010. 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Management of a patient with an abnormal cervical smear - 2002 update__Clinical Practice Guidelines. Published online 2002. 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[Evaluation of Papillomavirus research (HPV) in cervical precancerous and cancerous lesions primary screening and the place of double immunostaining p16\/Ki67]. Published online July 10 2019. 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