{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:33:55Z","timestamp":1793165635714,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The importance of understanding the presentation of obstructive sleep apnea (OSA) in women has been increasingly recognized. Although there is some insight that there are significant differences in presentation between women and men, the consequences of such differences, particularly for treatment have not yet been fully identified. Thus, the objective of this study was to determine the phenotype of OSA in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Study of a population-based clinical cohort of 2022 patients with OSA confirmed by polygraphy or polysomnography (apnea\u2013hypopnea index [AHI] &gt;5\/hour). Comorbidities, symptoms, physical examination, current medical treatments, and sleep parameters were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 709 women and 1313 men were included in this study. After adjustment for anthropometric characteristics, morphological alterations, and previous treatment, women were found to have lower AHI values (25.3\u2009\u00b1\u20091.2 vs. 35.0\u2009\u00b1\u20090.9;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), desaturation index (24.4\u2009\u00b1\u20091.2 vs. 33.2\u2009\u00b1\u20090.9;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and saturation time &lt;90% (18.8\u2009\u00b1\u20091.3 vs. 24.1\u2009\u00b1\u20091.0;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with men. Furthermore, women had a lower risk of witnessed apnea (odds ratio adjusted [ORa] for baseline characteristics and sleep parameters), (ORa: 0.53, 95% confidence interval [CI]: 0.40\u20130.71), reduced sensation of restful sleep (ORa: 0.50, 95% CI: 0.38\u20130.66), greater fatigue (ORa: 2.68, 95% CI: 1.86\u20133.86), headache (ORa: 3.00, 95% CI: 2.26\u20133.97), memory disorders (ORa: 1.836, 95% CI: 1.40\u20132.41), insomnia (ORa: 2.09, 95% CI: 1.50\u20132.93), and excessive daytime sleepiness (ORa: 1.41, 95% CI: 1.03\u20131.92), with interference in their daily activities (ORa: 1.54, 95% CI: 1.17\u20132.03). Likewise, after adjustment for anthropometric characteristics and sleep parameters, women also showed higher risk of depression (ORa: 4.31, 95% CI: 3.15\u20135.89) and anxiety (ORa: 3.18, 95% CI: 2.38\u20134.26).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings suggest that women present a specific OSA phenotype, with a probable implication for clinical, diagnostic, and therapeutic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2021.0659","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T13:32:29Z","timestamp":1664285549000},"page":"1782-1790","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Defining the Profile of Obstructive Sleep Apnea in Women Compared to Men"],"prefix":"10.1177","volume":"31","author":[{"given":"Sofia","family":"Romero-Peralta","sequence":"first","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."},{"name":"Sleep Research Institute, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda-Rio","sequence":"additional","affiliation":[{"name":"Pneumology Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Resano Barrio","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Izquierdo Alonso","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."},{"name":"Department of Medicine and Specialties, University of Alcal\u00e1, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Esther","family":"Viejo-Ayuso","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mediano San Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Silgado Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"\u00c1lvarez Balado","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Castelao","family":"Naval","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Fern\u00e1ndez Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mediano","sequence":"additional","affiliation":[{"name":"Sleep Unit, Pneumology Service, University Hospital of Guadalajara, Guadalajara, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain."},{"name":"Department of Medicine and Specialties, University of Alcal\u00e1, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2021.03.017"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2001008"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-702OC"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-637OC"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.06.11"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00212711"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1019478"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3.697"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.9.1173"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.suppl_8.s1"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00410.2004"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.6.1986"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.2.305"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.3.312"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-008-0184-8"},{"issue":"3","key":"e_1_3_7_17_2","first-page":"309","article-title":"Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome","volume":"28","author":"Shepertycky MR","year":"2005","unstructured":"Shepertycky MR, , Banno K, , Kryger MH. Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep, 2005; 28(3):309\u2013314; PMID: 16173651.","journal-title":"Sleep"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440200055007"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.03.002"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.01.002"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9904121"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-017-1482-9"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1992.tb00009.x"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2012OC"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159207"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.8118642"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633730"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2011.01.001"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-017-1612-4"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2896(08)75778-8"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1550-8579(07)80062-3"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2021.02.022"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.1.204"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27650"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.13175\/swjpcc082-16"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.9911064"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2408"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046710"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325664"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1270"}],"container-title":["Journal of Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jwh.2021.0659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2021.0659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2021.0659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:56:46Z","timestamp":1777658206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jwh.2021.0659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1089\/jwh.2021.0659"],"URL":"https:\/\/doi.org\/10.1089\/jwh.2021.0659","relation":{},"ISSN":["1540-9996","1931-843X"],"issn-type":[{"value":"1540-9996","type":"print"},{"value":"1931-843X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}