{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:27:50Z","timestamp":1782307670529,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2024,2]]},"abstract":"\n Objective:<\/jats:title>\n \n With a global incidence of more than 10%, preterm birth (PTB) remains a significant concern. The vaginal microbiome strongly influences the well-being of the female reproductive tract. This study examines the correlation between changes in\n Lactobacillus<\/jats:italic>\n vaginal microbiota and the PTB risk.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n A thorough search of PubMed, Web of Science, Cochrane Library, and EMBASE was conducted to locate studies that examined the association between changes in\n Lactobacillus<\/jats:italic>\n vaginal microbiota and the risk of PTB from January 1, 2010, to January 30, 2023. The risk of PTB was determined by calculating odds ratios (ORs) with 95% confidence intervals (CIs).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In our analysis, there were 11 studies with 1577 pregnant women. The findings revealed a significant negative correlation between higher\n Lactobacillus<\/jats:italic>\n abundance and the PTB risk (OR\u2009=\u20090.49, 95% CI: 0.29\u20130.84,\n p<\/jats:italic>\n \u2009=\u20090.009\u2009<\u20090.05). Similarly, the four individual dominant species,\n Lactobacillus crispatus<\/jats:italic>\n (OR\u2009=\u20090.3, 95% CI: 0.14\u20130.67,\n p<\/jats:italic>\n \u2009=\u20090.003\u2009<\u20090.05),\n Lactobacillus gasseri<\/jats:italic>\n (OR\u2009=\u20090.34, 95% CI: 0.17\u20130.69,\n p<\/jats:italic>\n \u2009=\u20090.003\u2009<\u20090.05),\n Lactobacillus iners<\/jats:italic>\n (OR\u2009=\u20090.68, 95% CI: 0.49\u20130.93,\n p<\/jats:italic>\n \u2009=\u20090.016\u2009<\u20090.05), and\n Lactobacillus jensenii<\/jats:italic>\n (OR\u2009=\u20090.43, 95% CI: 0.21\u20130.89,\n p<\/jats:italic>\n \u2009=\u20090.024\u2009<\u20090.05), were also negatively associated with the PTB risk. The risk of\n Lactobacillus<\/jats:italic>\n for PTB was significant in both America (OR\u2009=\u20090.67; 95% CI: 0.50\u20130.92) and Asia (OR\u2009=\u20090.20; 95% CI: 0.09\u20130.47), whereas no significant risk was found in Europe (OR\u2009=\u20090.49; 95% CI: 0.11\u20132.15).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Our study demonstrated that the abundance of\n Lactobacillus<\/jats:italic>\n and the four dominant individual species (\n L. crispatus<\/jats:italic>\n ,\n L. jensenii<\/jats:italic>\n ,\n L. iners<\/jats:italic>\n , and\n L. gasseri<\/jats:italic>\n ) were significantly and negatively associated with the PTB risk.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/jwh.2023.0393","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T13:39:32Z","timestamp":1702042772000},"page":"228-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship of\n Lactobacillus<\/i>\n Vaginal Microbiota Changes and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"33","author":[{"given":"Qian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04552-y"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-022-01248-2"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30451-0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265146"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-064547"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741411"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705899114"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.5327\/DST-2177-8264-20223407"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0450-2"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"issue":"1","key":"e_1_3_5_12_2","first-page":"7","article-title":"Antimicrobial activity and characteristics of bacteriocins produced by vaginal lactobacilli","volume":"33","author":"Aydin F","year":"2003","unstructured":"Karao\u011flu \u015eA, Aydin F, , Kilic SS, et al. 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