{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:25:35Z","timestamp":1780694735319,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine subclinical cardiovascular disease (sCVD) in middle-aged women with clinically manifested hand osteoarthritis (HOA) and to improve the characterization of cardiovascular risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We cross-sectionally evaluated the relationship between HOA and sCVD in 1,803 volunteers from the Mexican Teachers\u2019 Cohort. From 2012 to 2016, a subsample from Mexico City, the Northern state Nuevo Le\u00f3n, and the Southern states Chiapas and Yucat\u00e1n was invited for clinical evaluations, during which neurologists examined carotid arteries using ultrasound, and a standardized HOA questionnaire was also administered. HOA was defined as age \u226545 years, hand joint pain, and morning stiffness that lasted no longer than 30 minutes. sCVD was assessed using the intima-media thickness (IMT) and atherosclerotic plaques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among participants with a mean age of 51 years (\u00b14), 18.4% met the criteria for HOA, and the prevalence of carotid atherosclerosis was 23.1%. After multivariable adjustment, women diagnosed with HOA had a 1.8% (95% confidence interval [CI] 0.3, 3.3) greater mean IMT than those without this joint disease. Similarly, women with HOA had 36% (95% CI 1.01, 1.84) higher odds of carotid atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>HOA is associated with sCVD in middle-aged women. This relationship might be due to low-grade chronic inflammation; however, further research is required to clarify the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2023.1088","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T13:24:28Z","timestamp":1727702668000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hand Osteoarthritis and Subclinical Cardiovascular Disease in Middle-Aged Women"],"prefix":"10.1177","volume":"34","author":[{"given":"Rodrigo Rafael","family":"Flores-Marinelarena","sequence":"first","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Mexico City, Mexico."},{"name":"Department of Internal Medicine, Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Sofia","family":"Rodr\u00edguez-Reyna","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cant\u00fa-Brito","sequence":"additional","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Mexico City, Mexico."},{"name":"Division of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Lajous","sequence":"additional","affiliation":[{"name":"Center for Research on Population Health, National Institute of Public Health, Mexico City, Mexico."},{"name":"Department of Global Health and Population, Harvard T.H. 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