{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:07:46Z","timestamp":1779196066145,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Portal venous system thrombosis (PVST) is a common and potentially life-threatening complication of splenectomy for portal hypertension due to cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A meta-analysis was conducted to study the necessity of pharmacologic prophylaxis of PVST after splenectomy and how to select the feasible treatment method. Articles were searched through the PubMed, EMBASE, Cochrane Library databases, and CNKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, 404 articles were initially identified, and 11 of them were eligible. Among these selected articles, 7 articles were associated with the necessity of anticoagulation for prevention of PVST, while 5 were about the drug selection. We first demonstrated that the incidence of PVST after splenectomy was significantly lower in patients who received the preventive measures than in those who did not (odds ratio [OR]: 0.22, 95% confidence interval [CI]: 0.13\u20130.39,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001). Then, we compared the new-style treatment with the conventional treatment and found that patients with new therapy method had lower incidence of PVST than those who received conventional treatment (OR: 0.37, 95% CI: 0.27\u20130.51,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001). Also, some studies (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094) reported that early and combination use of anticoagulation drugs can lead to better outcome for patients with splenectomy and devascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preventative use of anticoagulant drugs might decrease the incidence of PVST after splenectomy in patients with portal hypertension, new anticoagulant drugs such as low-molecular-weight heparin should be used, and early or combination use of anticoagulation drugs might lead to lower PVST incidence for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lap.2016.0511","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T16:25:46Z","timestamp":1487262346000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effective Prevention for Portal Venous System Thrombosis After Splenectomy: A Meta-Analysis"],"prefix":"10.1177","volume":"27","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhao","family":"Huang","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Deng","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanzhou","family":"Xue","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhengzhou University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2012.0268"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4523-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.07.939"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.861067"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480006600511"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1190-x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v23.i1.129"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24766"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7002"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/292689"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/89.9.873"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.049909"},{"key":"e_1_3_3_16_2","first-page":"524","article-title":"Effects of alprostadil in prevention of portal vein thrombogenesis after splenectomy and devascularization: A clinical observation of 76 patients with portal hypertension","volume":"88","author":"Ma J-C","year":"2008","unstructured":"Ma J-C, , Zhao J, , Su Q-H, , Zhang D-H, , Guo Y, , Ji Z-Z. Effects of alprostadil in prevention of portal vein thrombogenesis after splenectomy and devascularization: A clinical observation of 76 patients with portal hypertension. Natl Med J China, 2008; 88:524\u2013526.","journal-title":"Natl Med J China"},{"key":"e_1_3_3_17_2","first-page":"855","article-title":"Portal anticoagulation in preventing thrombosis after porta-azygous devascularization for portal hypertension","volume":"38","author":"Xue H","year":"2000","unstructured":"Xue H, , Zhang H., , Zhang Y, , Jiang Q. Portal anticoagulation in preventing thrombosis after porta-azygous devascularization for portal hypertension. Zhonghua Wai Ke Za Zhi, 2000; 38:855\u2013857.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"e_1_3_3_18_2","first-page":"23","article-title":"Clinical observation of low-molecular heparin preventing pylethrombosis after peri-esophagogastric devascularization and splenectomy","author":"Jian Y","year":"2012","unstructured":"Jian Y, , Lin Z. Clinical observation of low-molecular heparin preventing pylethrombosis after peri-esophagogastric devascularization and splenectomy. 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