{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:02:23Z","timestamp":1777921343653,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Traditional intersphincteric resection is a technically demanding procedure that required a perineal approach dissection and a handsewn coloanal anastomosis. Our study was to investigate the feasibility and the prognostic factors of completely abdominal approach partial intersphincteric resection (APISR) after neoadjuvant chemoradiotherapy (CRT) for low rectal cancer with initial stage cT3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 101 consecutive patients with initial stage cT3 juxta-anal rectal cancer who underwent APISR after neoadjuvant CRT between January 2010 and March 2015 were enrolled. Survival rates were estimated and compared using the Kaplan\u2013Meier method and log-rank tests. Cox proportional hazard model was utilized for multivariable analysis for disease-free survival (DFS). The cutoff values of residual tumor size calculated by X-tile were used in the multivariate analysis as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median follow-up was 39 months. The local recurrence rate within 3 years was 2.5%. The 3-year DFS rate was 80.2%, and the 3-year overall survival rate was 95.3%. The 3-year DFS in pathological stage 0\u2013III were 96.2%, 94.4%, 85.7%, and 44.7% respectively (Log-rank\u2009=\u200929.791,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In multivariate analysis, stage ypN1-2 (hazard ratio (HR)\u2009=\u20098.256, 95% confidence interval [CI]: 2.742\u201324.855,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and tumor size after CRT more than 2.8\u2009cm (HR\u2009=\u20093.077, 95% CI: 1.036\u20139.137,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.043) were the independent factors for worse DFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Laparoscopic and open APISR after CRT produces satisfactory mid-term oncological outcomes for juxta-anal rectal cancer downstaged from initial cT3 especially in stage ypN0 or with tumor size after CRT &lt;2.8\u2009cm. Hence, stage ypN1\u20132 and tumor size after CRT more than 2.8\u2009cm are poor prognostic factors that should be estimated for APISR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lap.2018.0606","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T16:47:00Z","timestamp":1546274820000},"page":"809-816","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Completely Abdominal Approach Laparoscopic Partial Intersphincteric Resection After Neoadjuvant Chemoradiation for Initial cT3 Juxta-Anal Rectal Cancer"],"prefix":"10.1177","volume":"29","author":[{"given":"Shenghui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingrong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongbin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanwu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"361","article-title":"A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon","volume":"21","author":"Miles WE","year":"1971","unstructured":"Miles WE. 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