{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:22:38Z","timestamp":1790126558464,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The injection of tissue adhesives has been proposed as an alternative to standard laparoscopic inguinal hernia repair but no evidence is available in the pediatric population. This study aimed to evaluate safety, efficacy, and feasibility of injection of tissue adhesives for inguinal hernia repair in a rabbit model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-six New Zealand White male rabbits underwent laparoscopic inguinal hernia repair. In each animal, the hernia defect was repaired using glue on the right side and purse-string suture on the left side. The animals were divided in 3 groups, each 1 of 12 animals, according to the glue used: Glubran 2\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (cyanoacrylate), Histoacryl\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (cyanoacrylate), and BioGlue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (bovine serum albumin-based). For each group, 6 animals were sacrificed at 7 days postoperatively, and 6 animals at 90 days postoperatively. Histopathological exam of testis and spermatic bundle was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The hernia defect was successfully closed on both sides in all cases. The injection of glue was faster than suture repair (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001). Postoperative complications (epiploon-parietal adhesions, spermatic vessel ectasia, and hydrocele) rate was significantly higher on the right side compared to the left side at both short- and long-term follow-up (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001). Furthermore, a lower maturity of testicles treated by adhesive compared with suture was histologically demonstrated at both short- and long-term follow-up (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The present experimental study confirmed the feasibility and efficacy of inguinal hernia repair by injection of tissue adhesive. However, several critical issues emerged about the safety of this technique. The use of glue was associated with higher incidence of postoperative complications and significant decrease of testicular maturity compared with standard suture repair. Based upon these preliminary results, repair using suture remains the standard of care for inguinal hernia in children. Further experimental studies are needed to assess the safety of injection of tissue adhesives for pediatric inguinal hernia repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lap.2020.0015","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:36:04Z","timestamp":1588962964000},"page":"847-853","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Laparoscopic Injection of Tissue Adhesives for Inguinal Hernia Repair in a Rabbit Model: Results of an Experimental Comparative Study with the Standard Laparoscopic Inguinal Hernia Repair"],"prefix":"10.1177","volume":"30","author":[{"given":"Maria","family":"Escolino","sequence":"first","affiliation":[{"name":"Pediatric Surgery Unit, Federico II University of Naples, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Esposito","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Federico II University of Naples, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Eaton","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Great Ormond Street Hospital, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Di Maro","sequence":"additional","affiliation":[{"name":"Center of Biotechnologies, Cardarelli Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santolo","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Center of Biotechnologies, Cardarelli Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Vitagliano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Federico II University of Naples, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Armiento","sequence":"additional","affiliation":[{"name":"Department of Public Health and Federico II University of Naples, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federico II University of Naples, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"De Coppi","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Great Ormond Street Hospital, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90664-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2014.0194"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30842"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2005.15.424"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.10.040"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.08.018"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2006.0107"},{"key":"e_1_3_4_9_2","first-page":"155","article-title":"A single-surgeon randomized trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair","volume":"53","author":"Testini M","year":"2010","unstructured":"Testini M, , Lissidini G, , Poli E, , Gurrado A, , Lardo D, , Piccinni G. A single-surgeon randomized trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair. Can J Surg, 2010; 53:155\u2013160.","journal-title":"Can J Surg"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-009-0524-z"},{"key":"e_1_3_4_11_2","first-page":"159","article-title":"The injection treatment of hernia","volume":"9","author":"Patterson DC","year":"1936","unstructured":"Patterson DC. The injection treatment of hernia. Yale J Biol Med, 1936; 9:159\u2013166.","journal-title":"Yale J Biol Med"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36312-7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9719-6"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100505"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90321-4"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6706.1014"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010287"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-003-9032-x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2014.08.011"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2015.0521"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2015.0229"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00339559"}],"container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lap.2020.0015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lap.2020.0015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lap.2020.0015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:53:55Z","timestamp":1777665235000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lap.2020.0015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,1]]}},"alternative-id":["10.1089\/lap.2020.0015"],"URL":"https:\/\/doi.org\/10.1089\/lap.2020.0015","relation":{},"ISSN":["1092-6429","1557-9034"],"issn-type":[{"value":"1092-6429","type":"print"},{"value":"1557-9034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}