{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:03:45Z","timestamp":1777921425787,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Few adverse effects may occur after bariatric surgery, one being the formation of gallstones. The aim of this study is to determine the incidence of cholelithiasis after laparoscopic sleeve gastrectomy (LSG) and whether ursodeoxycholic acid (UDCA) treatment reduces gallstone formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Gall bladders of all patients planned for LSG were preoperatively checked by ultrasonography (USG). Patients who had no documented gallbladder pathology before LSG and who had USG at 12th month and 2 years follow-up after LSG were included in the study. The incidences of newly developed cholelithiasis, cholecystectomy, and endoscopic retrograde cholangiopancreatography (ERCP) requirement in patients who did not receive any UDCA treatment (pre-2015 protocol,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009128) was compared with the corresponding numbers in patients who regularly used 500\u2009mg\/day oral UDCA for 6 months after the LSG (post-2015 protocol,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009152).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Between January 2012 and October 2018, 717 LSGs were performed in two centers and after exclusions, 280 patients were eligible for evaluation. Sixty-four of 280 (23%) patients developed cholelithiasis after LSG and cholecystectomy was performed in 24 patients (8.6%) for symptomatic cholelithiasis. In the non-UDCA group, 48 patients developed cholelithiasis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200948\/128, 37.5%) compared with 16 patients in the UDCA group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200916\/152, 10.5%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Compared with 5 patients in the UDCA group, 19 patients underwent cholecystectomy (39.6%) in the non-UDCA group due to symptomatic cholelithiasis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.55) and 5 of these patients also required an ERCP. No ERCP became necessary in the UDCA group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>An almost fourfold decrease in the rate of new gall stone formation with 500\u2009mg daily UDCA treatment was impressive and may suggest routine UDCA treatment after LSG. Given the rate of exclusions and follow-up differences among the groups, certainly, randomized trials, with less exclusion are needed to provide conclusive evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lap.2020.0077","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T16:55:07Z","timestamp":1585673707000},"page":"1150-1152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Cholelithiasis After Sleeve Gastrectomy and Effectiveness of Ursodeoxycholic Acid Treatment"],"prefix":"10.1177","volume":"30","author":[{"given":"Ozan","family":"\u015een","sequence":"first","affiliation":[{"name":"T\u00fcrk\u00e7apar Bariatrics, Obesity Center, \u0130stanbul, Turkey."},{"name":"\u0130stanbul Bariatrics, Obesity and Advanced Laparoscopy Center, \u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet G\u00f6khan","family":"T\u00fcrk\u00e7apar","sequence":"additional","affiliation":[{"name":"T\u00fcrk\u00e7apar Bariatrics, Obesity Center, \u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Yerdel","sequence":"additional","affiliation":[{"name":"\u0130stanbul Bariatrics, Obesity and Advanced Laparoscopy Center, \u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2666-x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2017.12.013"},{"key":"e_1_3_3_4_2","first-page":"153","article-title":"Gallstones in patients with morbid obesity: Relationship to body weight, weight loss and gallbladder bile cholesterol solubility","author":"Shiffman ML","year":"1993","unstructured":"Shiffman ML, , Sugerman HJ, , Kellum JH, et al. 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