{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:23:53Z","timestamp":1781382233860,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2022,11,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The aim of this study was to compare the long-term outcomes of laparoscopic complete (Nissen) fundoplication (LNF) with laparoscopic partial (Thal) fundoplication (LTF) in children. This is the only prospective, randomized study to follow patients up for more than 10 years. Interim results published in 2011 at median 2.5 year follow-up showed that LNF had a significantly lower failure rate compared with LTF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A randomized, controlled trial of LNF versus LTF in children (&lt;16 years) was performed. The primary outcome measure was \u201cabsolute\u201d failure of the fundoplication\u2014recurrence of symptoms that merited either reoperation or insertion of transgastric jejunostomy (GJ). Secondary outcomes were \u201crelative\u201d failure (need for postop antireflux medication), complications (e.g., dysphagia), and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      One hundred seventy-five patients were recruited; 89 underwent LNF, and 86 underwent LTF. Eight patients had no follow-up recorded. At long-term follow-up, 59 patients had died (35%); LNF 37\/85 (43.5%) and LTF 22\/82 (26.8%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.02. Median length of follow-up in survivors was 132 months. There was no statistically significant difference in \u201cabsolute\u201d failure rate between LNF 8\/85(9.4%) and LTF 15\/82 (18%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.14. There was no difference in \u201crelative\u201d failure between LNF 7\/85 (8.2%) and LTF 12\/82 (14%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.23. Long-term dysphagia affected 5 out of 108 (4.6%) patients; 3\/48 (6.2%) of LNF and 2\/60 (3.3%) of LTF (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There was no statistically significant difference in \u2018absolute\u2019 failure between LNF and LTF at long-term follow-up. Neurologically impaired children have a high mortality rate following fundoplication due to comorbidities.<\/jats:p>\n                    <jats:p>This trial commenced in 1998 and was approved by the Oxfordshire Research Ethics Committee (No. 04.OXA.18-1998).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lap.2022.0083","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:14:35Z","timestamp":1663694075000},"page":"1183-1189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["10 Year Follow-Up of Randomized Trial of Laparoscopic Nissen Versus Thal Fundoplication in Children"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-4344","authenticated-orcid":false,"given":"Clare","family":"Skerritt","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery, Oxford Children's Hospital, Oxford Radcliffe NHS Trusts, Oxford, United Kingdom."},{"name":"Department of Paediatric Surgery, Bristol Royal Hospital for Children, Bristol, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Sui","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Oxford Children's Hospital, Oxford Radcliffe NHS Trusts, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-321X","authenticated-orcid":false,"given":"Rainer","family":"Kubiak","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Oxford Children's Hospital, Oxford Radcliffe NHS Trusts, Oxford, United Kingdom."},{"name":"Department of Paediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-Wurttemberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare M.","family":"Rees","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Imperial College Healthcare NHS Trust, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh W.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Oxford Children's Hospital, Oxford Radcliffe NHS Trusts, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"351","article-title":"Laparoscopic Nissen fundoplication in childhood","volume":"28","author":"Lobe TE","year":"1993","unstructured":"Lobe TE, , Schropp KP, , Lunsford K. 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