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Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.<\/jats:p>","DOI":"10.1089\/lrb.2009.0022","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T08:18:33Z","timestamp":1265703513000},"page":"215-219","source":"Crossref","is-referenced-by-count":41,"title":["Lymphatics in Human Lymphatic Filariasis:\n                    <i>In Vitro<\/i>\n                    Models of Parasite-Induced Lymphatic Remodeling"],"prefix":"10.1177","volume":"7","author":[{"given":"Sasisekhar","family":"Bennuru","sequence":"first","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(00)01778-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00022860"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(67)90162-9"},{"key":"e_1_3_2_5_2","first-page":"267","article-title":"Specific hypo-responsive granulomatous tissue reactions in Brugia pahangi-infected jirds","volume":"38","author":"Klei TR","year":"1981","unstructured":"Klei TR, , Enright FM, , Blanchard DP, , Uhl SA. 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