{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:08Z","timestamp":1792124888789,"version":"4.4.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The manual lymphatic drainage in lymphedema has proved to be successful; however, this method cannot be applied to millions of patients around the world. The only solution is to offer inexpensive, easily accessible mechanical devices for pneumatic compression (IPC). These devices should be designed on parameters of edema fluid hydromechanics. Recent data point to high pressures and long time of compression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To validate the effects of 3 years daily high pressure, long inflation time IPC therapy in terms of decrease of limb circumference\/volume, tissue elasticity, histological changes, and incidental complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A group of 18 patients with unilateral leg lymphedema stage II to IV was treated for a period of 3 years using an 8-chamber sleeve, sequential inflation of chambers to 100\u2013120\u2009mmHg for 50\u2009sec (total 400\u2009sec). Limb circumference and tissue tonicity were measured at monthly intervals. Correlation between decrease in calf and thigh circumference and increase in elasticity was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The treatment revealed durable permanent decrease of limb circumference and increased elasticity of tissues. The improvement was most expressed in the calf above the ankle and mid-calf. No complications as thigh ring or chronic genital edema were observed. There was no direct correlation between the decrease in limb circumference and increase in elasticity, most likely due to different mass of fibrous tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>IPC takes over the permanently missing function of the obliterated lymphatics by squeezing edema tissue fluid to the regions with normal lymphatic drainage. The limb circumference is decreased or at least does not further increase, elasticity of tissue is increased and maintained. No complications in limb tissues were observed. The long-term, high pressure IPC, long inflation timed therapy can be safely be recommended to patients with lower limb lymphedema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2013.0033","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T14:45:01Z","timestamp":1402670701000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":87,"title":["The Effectiveness of Intermittent Pneumatic Compression in Long-Term Therapy of Lymphedema of Lower Limbs"],"prefix":"10.1177","volume":"12","author":[{"given":"Marzanna","family":"Zaleska","sequence":"first","affiliation":[{"name":"Central Clinical Hospital","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar L.","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Central Clinical Hospital","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Durlik","sequence":"additional","affiliation":[{"name":"Central Clinical Hospital","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2008.1023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0025"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0016"},{"key":"e_1_3_2_5_2","first-page":"395","article-title":"Tissue fluid and lymph space pressure\/volume relationship in obstructive lymphedema of lower limbs","volume":"40","author":"Olszewski WL","year":"2007","unstructured":"Olszewski WL, , Zaleska M, , Cakala M, , Victor J, , Tripathi M. Tissue fluid and lymph space pressure\/volume relationship in obstructive lymphedema of lower limbs. Lymphology, 2007; 40:395.","journal-title":"Lymphology"},{"key":"e_1_3_2_6_2","first-page":"13","article-title":"Intermittent pneumatic compression therapy: A systemic review","volume":"45","author":"Feldman JL","year":"2012","unstructured":"Feldman JL, , Stout NL, , Wanchai A, , Stewart BR, , Cormier JN, , Armer JM. Intermittent pneumatic compression therapy: A systemic review. Lymphology, 2012; 45:13\u201325.","journal-title":"Lymphology"},{"key":"e_1_3_2_7_2","first-page":"42","article-title":"Comparative efficacy of different types of pneumatic compression pumps for the treatment of lymphedema","author":"Special report","year":"1998","unstructured":"Special report: Comparative efficacy of different types of pneumatic compression pumps for the treatment of lymphedema. Technologica MAP Suppl, 1998:42\u201343.","journal-title":"Technologica MAP Suppl"},{"key":"e_1_3_2_8_2","unstructured":"Centers for Medicare and Medicaid Services (CMS). National Coverage Determination for Pneumatic Compression Devices Publication number 100-3 Manual section number 280.6."},{"key":"e_1_3_2_9_2","unstructured":"Blue Cross and Blue Shield Association Technology Assessment Program (TEC). Special report: Comparative efficacy of different types of pneumatic compression pumps for the treatment of lymphedema. 1998:2."},{"key":"e_1_3_2_10_2","unstructured":"Palmetto GBA-Statistical Analysis Durable Medical Equipment Carrier (SADMERC). Durable Medical Equipment Coding System (DMECS) Product Search for HCPCS codes E0650 E0651 E0652. Retrieved from http:\/\/www3.palmettogba.com\/dmecs\/do\/productsearch."},{"key":"e_1_3_2_11_2","unstructured":"National Lymphedema Network (NLN). Position statement of the national lymphedema network. Treatment. 2006 August 10. 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McMaster University Evidence-based Practice Center under contract to the Agency for Healthcare Research and Quality Technology Assessment Blue Cross of Idaho MP 1.01.18 Pneumatic Compression Pumps for Treatment of Lymphedema."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2010.8407"},{"key":"e_1_3_2_22_2","first-page":"1","article-title":"Exploration of the mechanism underlying neogenesis and regeneration of postnatal mammalian skin","volume":"16","author":"Chunyi LI","year":"2010","unstructured":"Chunyi LI. Exploration of the mechanism underlying neogenesis and regeneration of postnatal mammalian skin. 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Lymphology, 1998; 31:15\u201320.","journal-title":"Lymphology"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300384"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2013.0033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2013.0033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2013.0033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:09:25Z","timestamp":1777666165000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2013.0033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6,1]]}},"alternative-id":["10.1089\/lrb.2013.0033"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2013.0033","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]}}}