{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:14:09Z","timestamp":1777922049642,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lymphatic filariasis is the leading cause of secondary lymphedema wherein lymph transport is impaired due to lymphatic damage.\n                    <jats:italic toggle=\"yes\">FLT4<\/jats:italic>\n                    signaling and transcription factors such as\n                    <jats:italic toggle=\"yes\">FOXC2<\/jats:italic>\n                    play an important role in this type of lymphangiogenesis process induced by filarial parasites. The present study aims to assess the association of\n                    <jats:italic toggle=\"yes\">FLT4<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">FOXC2<\/jats:italic>\n                    genes in lymphatic development\/remodeling in lymphatic filariasis. A total of 118 lymphatic filariasis patients and 100 non-endemic and 50 endemic healthy subjects were enrolled for the present study. Allele-specific PCR and PCR-RFLP were adopted for the genotyping, and screening of\n                    <jats:italic toggle=\"yes\">FLT4<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">FOXC2<\/jats:italic>\n                    genes was carried out by PCR-SSCP, followed by\n                    <jats:italic toggle=\"yes\">in-silico<\/jats:italic>\n                    and statistical analysis. A novel variation (G357A SNP) was identified on\n                    <jats:italic toggle=\"yes\">FOXC2<\/jats:italic>\n                    gene screening that may have an effect on codon usage frequency during translational process. In\n                    <jats:italic toggle=\"yes\">FLT4,<\/jats:italic>\n                    A3123G mutation was found in 3.39% of the case subjects but the functional role of this mutation, along with subject's clinical presentations and patient's age, emphasize its pathogenic role in lymphedema development. Two of the subjects exhibit compound heterozygosity (A3123G\n                    <jats:italic toggle=\"yes\">FLT4<\/jats:italic>\n                    mutation and G357A SNP of\n                    <jats:italic toggle=\"yes\">FOXC2<\/jats:italic>\n                    gene). As these two genes share a common pathway, we hypothesise a synergistic interaction of these two SNPs in inhibiting the downstream signaling resulting in lymphedema progression.\n                  <\/jats:p>","DOI":"10.1089\/lrb.2014.0025","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T14:35:27Z","timestamp":1434724527000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>FOXC2<\/i>\n                    and\n                    <i>FLT4<\/i>\n                    Gene Variants in Lymphatic Filariasis"],"prefix":"10.1177","volume":"13","author":[{"given":"Yasmeen","family":"Sheik","sequence":"first","affiliation":[{"name":"Osmania University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera Fatima","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Osmania University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basheeruddin","family":"Mohhammed","sequence":"additional","affiliation":[{"name":"NFCP (National Filariasis Control program Centre)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratibha","family":"Nallari","sequence":"additional","affiliation":[{"name":"Osmania University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00727-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.031047"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0022"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01133.x"},{"key":"e_1_3_3_7_2","first-page":"5","article-title":"Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: Implications for pathogenesis","author":"Bennuru S","year":"2009","unstructured":"Bennuru S, , Nutman TB. Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: Implications for pathogenesis. 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