{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:05:59Z","timestamp":1791774359218,"version":"4.3.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces. The intrinsic pump relies on spontaneous lymphatic contraction, which generates the pumping lymph pressure (P\n                      <jats:sub>lp<\/jats:sub>\n                      ). Among healthy people with daily leg edema, a considerable number of cases are accompanied with low leg P\n                      <jats:sub>lp<\/jats:sub>\n                      . Herein, a double-blinded controlled trial was conducted in healthy female volunteers with reduced leg P\n                      <jats:sub>lp<\/jats:sub>\n                      to compare the effectiveness of a 15\u201329\u2009mmHg compression stocking (Stocking A) and a 8\u201316\u2009mmHg stocking (Stocking B) on elevating P\n                      <jats:sub>lp<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and Results:<\/jats:title>\n                    <jats:p>\n                      Among 219 healthy female volunteers who underwent measurement of leg P\n                      <jats:sub>lp<\/jats:sub>\n                      , 80 participants (36.5%) had unilateral or bilateral legs with P\n                      <jats:sub>lp<\/jats:sub>\n                      &lt; 20\u2009mmHg (122 legs with P\n                      <jats:sub>lp<\/jats:sub>\n                      &lt; 20\u2009mmHg and 38 legs with P\n                      <jats:sub>lp<\/jats:sub>\n                      \u2267 20\u2009mmHg). These 80 participants were assigned to wear either Stocking A (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200940) or Stocking B (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200940) for 16 weeks. Leg P\n                      <jats:sub>lp<\/jats:sub>\n                      was measured using indocyanine green fluorescence lymphography and an occlusion cuff technique while sitting. At 16 weeks, both Stockings A and B resulted in significantly elevated leg P\n                      <jats:sub>lp<\/jats:sub>\n                      , with the effect on elevating P\n                      <jats:sub>lp<\/jats:sub>\n                      being superior for Stocking A. Only Stocking A resulted in decreased prevalence of leg edema and improved Short Form-36 scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Compression stockings may represent a therapeutic option to elevate leg P\n                      <jats:sub>lp<\/jats:sub>\n                      and ameliorate leg edema, thereby leading to improved quality of life in healthy females with low leg P\n                      <jats:sub>lp<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2015.0045","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T15:30:53Z","timestamp":1454081453000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Compression Stockings on Elevation of Leg Lymph Pumping Pressure and Improvement of Quality of Life in Healthy Female Volunteers: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"14","author":[{"given":"Ryota","family":"Sugisawa","sequence":"first","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Unno","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sano","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Katahashi","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Uranaka","sequence":"additional","affiliation":[{"name":"Toray Opelontex Co., Ltd.","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Marumo","sequence":"additional","affiliation":[{"name":"Toray Opelontex Co., Ltd.","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Konno","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)92038-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011557"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.04.067"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.05.051"},{"key":"e_1_3_3_9_2","unstructured":"Partsch H J\u00fcnger M. 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