{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:34:00Z","timestamp":1790094840995,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lymphedema is an irreversible inflammatory condition caused by accumulated lymph fluid and is associated with chronic swelling and increased risk of cellulitis. Our objectives were to: (1) describe the patient population referred to a Canadian lymphedema center and (2) compare lymphedema characteristics between patients with cancer and patients with noncancer diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted of new patients referred for suspected lymphedema to a hospital-based center over a 2-year period. The mean age of the patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009429) was 61.4 years; 85% were female and 81% had a history of cancer. Lymphedema characteristics were primary (7%) versus secondary (92%); upper body (51%) versus lower body (45%); unilateral (74%) versus bilateral (25%); and history of cellulitis (22%). Patients with noncancer diagnoses (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200982) were more likely than patients with cancer diagnoses (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009347) to have a history of cellulitis (44% vs. 17%), to have bilateral (61% vs. 16%) and lower limb (89% vs. 37%) lymphedema, and to experience a long delay between symptom onset and referral (14.0 vs. 3.5 years) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Most patients referred to our lymphedema center were female with a history of cancer. However, patients with noncancer diagnoses were more likely to have bilateral lower body lymphedema with an important history of cellulitis; this subgroup is at great risk of missed and delayed diagnoses in the medical setting and of experiencing long-term issues with mobility, recurrent hospitalizations, and poor quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2016.0023","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T14:08:02Z","timestamp":1485785282000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparisons Between Cancer-Related and Noncancer-Related Lymphedema: An Overview of New Patients Referred to a Specialized Hospital-Based Center in Canada"],"prefix":"10.1177","volume":"15","author":[{"given":"Shirin M.","family":"Shallwani","sequence":"first","affiliation":[{"name":"McGill University Health Centre","place":["Canada"]},{"name":"McGill University Health Centre","place":["Canada"]},{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Hodgson","sequence":"additional","affiliation":[{"name":"McGill University Health Centre","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Towers","sequence":"additional","affiliation":[{"name":"McGill University Health Centre","place":["Canada"]},{"name":"McGill University","place":["Canada"]},{"name":"McGill University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Best Practice for the Management of Lymphoedema","author":"Lymphoedema Framework","year":"2006","unstructured":"Lymphoedema Framework. 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