{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:25:48Z","timestamp":1781198748796,"version":"3.54.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Gynecological cancer-related lymphedema (GCRL) is a devastating condition that adversely influences function, health, and quality of life. We conducted a randomized-controlled clinical study as well as\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      experiments to investigate the efficacy and safety of far infrared radiation (FIR) to treat lymphedema in patients having previously undergone surgery for gynecological tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Seventy-four women with GCRL, cancer free for 5 years or more, were randomly allocated into two treatment groups: standard of care with bandage treatment and treatment with FIR plus bandage. Variations of fluid, circumference of lymphedematous limbs, serum tumor markers (cancer antigen 125 [CA125]), inguinal-pelvic lymph nodes, vagina, lungs, and adverse reactions were assessed after 1 year.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      experiments examined the effects on cell viability, proliferation, apoptosis, and the cell cycle of fibroblast, A2780, SKOV-3, HELA, and Ishikawa cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The FIR+bandage group showed significantly decreased tissue fluid and reduced limb circumference (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in comparison with the control group at 1 year. There was no increase of serum CA125 in both groups, and no recurrence of neoplasia or lymphadenopathy was detected. No adverse reactions were recorded. In addition, no changes were detected after FIR treatment for fibroblast, A2780, SKOV-3, HELA, and Ishikawa cells in cell viability, proliferation, apoptosis, and cell cycle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FIR can be used to treat patients with GCRL following gynecological cancer treatment. Following clinical and experimental studies, we confirm that FIR is an oncologically safe treatment for lymphedema in gynecological tumor patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2019.0061","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:55:14Z","timestamp":1621857314000},"page":"164-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Far Infrared Radiation Therapy for Gynecological Cancer-Related Lymphedema Is an Effective and Oncologically Safe Treatment: A Randomized-Controlled Trial"],"prefix":"10.1177","volume":"20","author":[{"given":"Liang","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Oral and Cranio-Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic and Reconstructive Surgery, Fudan University, Eye &amp; ENT Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Rome \u201cTor Vergata,\u201d Rome, Italy."},{"name":"Department of Plastic and Reconstructive Surgery, Northumbria Healthcare NHS Foundation Trust, Northumberland, United Kingdom."},{"name":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom."},{"name":"Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary Hospital Newcastle NHS Foundation Trust, Newcastle upon Tyne, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Mousawi","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom."},{"name":"Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary Hospital Newcastle NHS Foundation Trust, Newcastle upon Tyne, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado Cesare","family":"Campisi","sequence":"additional","affiliation":[{"name":"Unit of Lymphatic Surgery, Department of Surgery, University of Genoa, IRCCS University Hospital San Martino-IST National Institute for Cancer Research, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Plastic Reconstructive and Aesthetic Surgery Unit, Villa Salaria Clinic, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1879-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-00009577-200605000-00028"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22684"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0018"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300384"},{"key":"e_1_3_4_7_2","first-page":"126","article-title":"Episodic dermatolymphangioadenitis (DLA) in patients with lymphedema of the lower extremities before and after administration of benzathine penicillin: A preliminary study","volume":"29","author":"Olszewski WL","year":"1996","unstructured":"Olszewski WL. 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