{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:15:59Z","timestamp":1777922159303,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>As survival from malignancies continues to improve, a greater emphasis is being placed on the quality of life after cancer treatments. Lymphedema (LE) represents a common and devastating sequela of neoplastic therapies, even if its incidence in patients submitted to lymphadenectomy for prostatic cancer is still poorly documented. The purpose of the current study was to analyze the imaging findings provided by noncontrast magnetic resonance (MR) lymphography in secondary lower limb LE related to prostate cancer therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Patients with diagnosed secondary LE related to prostatic cancer treatment who underwent noncontrast MR lymphography (NCMRL) between November 2019 and February 2020 were assessed. Image datasets were retrospectively reviewed for the severity of lymphedema and characteristics of the subcutaneous tissue, muscular compartment appearance, number of iliac and inguinal lymphatics, and number of locoregional lymph nodes. Ten patients with 17 affected lower extremities, nine right extremities, and eight left extremities were included in our analysis. Magnetic resonance imaging grading was classified as one in four extremities, two in five extremities, and three in eight lower extremities. Honeycomb pattern was observed in 15 extremities, without significant correlation with MR grading (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.684); dermal thickening showed correlation with MR grading (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as reduction of muscular trophism (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.021). We observed a significant correlation between the number of inguinal lymph nodes and recognizable inguinal lymphatics (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      NCMRL is able to provide useful information for the management of secondary lower limb LE caused by prostate cancer treatments. Clinical\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Trials.gov\">Trials.gov<\/jats:ext-link>\n                      ID: n.2019\/ST\/187\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0034","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T14:50:20Z","timestamp":1607439020000},"page":"355-361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Noncontrast Magnetic Resonance Lymphography in Secondary Lymphedema Due to Prostate Cancer"],"prefix":"10.1177","volume":"19","author":[{"given":"Michaela","family":"Cellina","sequence":"first","affiliation":[{"name":"Department of Radiology, Ospedale Fatebenefratelli, ASST Fatebenefratelli Sacco, Milan, Italy."},{"name":"Lymphedema Center, Nursing Home \u201cLa Madonnina\u201d, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Gibelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche per la Salute, Universit\u00e0 degli Studi di Milano, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Martinenghi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ospedale San Raffaele, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Soresina","sequence":"additional","affiliation":[{"name":"Lymphedema Center, Nursing Home \u201cLa Madonnina\u201d, Milan, Italy."},{"name":"Department of Plastic Surgery, Ospedale Fatebenefratelli, ASST Fatebenefratelli Sacco, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Menozzi","sequence":"additional","affiliation":[{"name":"Lymphedema Center, Nursing Home \u201cLa Madonnina\u201d, Milan, Italy."},{"name":"Department of Plastic Surgery, Ospedale Fatebenefratelli, ASST Fatebenefratelli Sacco, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisa","family":"Giardini","sequence":"additional","affiliation":[{"name":"Lymphedema Center, Nursing Home \u201cLa Madonnina\u201d, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ospedale Fatebenefratelli, ASST Fatebenefratelli Sacco, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.03.013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-001032"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.022"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2011.0007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64055-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36069-X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64161-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2017-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0085"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0047"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0042"},{"key":"e_1_3_3_13_2","first-page":"687","article-title":"Could MRI visualize the invisible? An Italian single center study comparing magnetic resonance lymphography (MRL), super microsurgery and histology in the identification of lymphatic vessels","volume":"21","author":"Gennaro P","year":"2017","unstructured":"Gennaro P, , Borghini A, , Chisci G, , Mazzei FG, , Weber E, , Tedone Clemente E, , Guerrini S, , Gentili F, , Gabriele G, , Ungari C, , Mazzei MA. Could MRI visualize the invisible? An Italian single center study comparing magnetic resonance lymphography (MRL), super microsurgery and histology in the identification of lymphatic vessels. Eur Rev Med Pharmacol Sci, 2017; 21:687\u2013694.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_14_2","author":"Guerrini S","unstructured":"Guerrini S, , Gentili F, , Mazzei FG, , Gennaro P, , Volterrani L, , Mazzei MA. Magnetic resonance lymphangiography: With or without contrast? 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