{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:16:02Z","timestamp":1777922162019,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Backgrounds:<\/jats:title>\n                    <jats:p>Axillary lymph node dissection (ALND) can cause breast cancer-related lymphedema (BCRL). However, ALND does not always produce lymphedema to the breast cancer survivors. Therefore, we aimed to investigate the correlation between the finding of lymphoscintigraphy and lymphedema in patients undergoing breast cancer surgery with ALND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Patients with BCRL (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200973, mean age: 53.92\u2009\u00b1\u200911.13 years) after full ALND (levels I, II, and III) were retrospectively included in this study. All patients underwent lymphoscintigraphy and according to the findings of the imaging, patients were divided into three groups: negative group, periclavicular lymph nodes (P-LN) activation, and axillary lymph nodes (A-LN) activation. According to the extent of radiation therapy, groups were classified as the following: no radiation group (None), breast radiation group (BI), and breast irradiation in addition to P-LN (BI+PC). The percentage difference in the upper extremities was used as the marker of severity of lymphedema. The subjects in the negative group, P-LN, and A-LN were 34 (46.6%), 33 (45.2%), and 6 (8.2%) patients, respectively. The findings of lymphangiography showed statistically significant relationship with the severity of lymphedema. The extent of radiation therapy did not have statistically significant relationship. Despite ALND, 53.4% patients had active L\/N capable of removing the upper limb lymphatic fluids and 45.2% patients showed activation of collateral formation of lymphatic circulation after ALND.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The collateral lymphatic formation was provoked after breast cancer operation with ALND, which decreased the severity of lymphedema in breast cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0040","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:47:17Z","timestamp":1601311637000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Periclavicular Lymph Node Activation Maintains the Lymphatic Circulation of Upper Extremity Following Breast Cancer Surgery with Axillary Lymph Node Dissection"],"prefix":"10.1177","volume":"19","author":[{"given":"Su Hwan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Surgery and College of Medicine, Yeungnam University, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30380-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328689"},{"key":"e_1_3_4_4_2","first-page":"1","article-title":"Axillary lymph node dissection for breast cancer: Efficacy and complication in developing countries","volume":"4","author":"Abass MO","year":"2018","unstructured":"Abass MO, , Gismalla MDA, , Alsheikh AA, , Elhassan MMA. Axillary lymph node dissection for breast cancer: Efficacy and complication in developing countries. J Glob Oncol, 2018; 4:1\u20138.","journal-title":"J Glob Oncol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.3517"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2012.11.007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199908000-00009"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03765.x"},{"key":"e_1_3_4_9_2","volume-title":"F\u00f6ldi's Textbook of Lymphology: For Physicians and Lymphedema Therapists","author":"F\u00f6ldi M","year":"2012","unstructured":"F\u00f6ldi M, , F\u00f6ldi E, , Str\u00f6\u00dfenreuther R, , Kubik S. F\u00f6ldi's Textbook of Lymphology: For Physicians and Lymphedema Therapists. New York: Elsevier Health Sciences; 2012."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1341"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S117830"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31815b6199"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/86.2.205"},{"key":"e_1_3_4_14_2","volume-title":"The Breast: Comprehensive Management of Benign and Malignant Diseases","author":"Bland KI","year":"2018","unstructured":"Bland KI, , Klimberg VS, , Copeland EM, , Gradishar WJ. The Breast: Comprehensive Management of Benign and Malignant Diseases. 5th ed. Philadelphia, PA: Elsevier; 2018."},{"key":"e_1_3_4_15_2","first-page":"33","article-title":"The incidence and risk factors for occurrence of arm lymphedema after treatment of breast cancer","volume":"110","author":"Rebegea L","year":"2015","unstructured":"Rebegea L, , Firescu D, , Dumitru M, , Anghel R. The incidence and risk factors for occurrence of arm lymphedema after treatment of breast cancer. Chirurgia (Bucur), 2015; 110:33\u201337.","journal-title":"Chirurgia (Bucur)"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.11.053"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1635118"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170391"},{"key":"e_1_3_4_19_2","first-page":"687","article-title":"Postoperative lymphoedema after treatment of breast cancer","volume":"149","author":"Brismar B","year":"1983","unstructured":"Brismar B, , Ljungdahl I. Postoperative lymphoedema after treatment of breast cancer. Acta Chir Scand, 1983; 149:687\u2013689.","journal-title":"Acta Chir Scand"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0452-2"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31828d7285"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.232"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2020.0040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:13:16Z","timestamp":1777666396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2020.0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6,1]]}},"alternative-id":["10.1089\/lrb.2020.0040"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2020.0040","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}