{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:20:02Z","timestamp":1778728802784,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary lower limb lymphedemas (LLLEs; not present at birth) are classified as early- and late-onset. In both groups, distal lymphangiopathy distal dermal backflow (DDB) may be observed and, in clinically unilateral edema, abnormalities may be present at the level of contralateral limb. The aim of this study is to report the frequency of heterolateral lesions in these patients based on lymphoscintigraphic investigations (LySc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Retrospective review (CE2048) among our database of patients who were referred for LySc of clinically unilateral LLLE and for whose LySc showed DDB. Fifty-six patients could be classified as early-onset (\u201cpraecox\u201d: group 1: 8 men and 48 women: median age at investigation\u2009=\u200932.5 years: edema was right sided in 26 and left sided in 30) and 47 (8 men and 39 women: edema was right sided in 25 and left sided in 22) as late-onset (\u201ctarda\u201d: group 2). DDB at the level of the opposite nonedematous limb was found in 38.8% of the whole series but more frequently (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in group 2 (70%) than in group 1 (15%). In group 1, bilateral disease were seen as frequently (in 4 cases) among the (33) patients &lt;35 years old than in other patients (4 out of 23).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These differences between these two clinical groups could support the following hypothesis: we are facing, either two different lymphatic diseases, or, a single disease but affecting two populations of different susceptibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0041","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T16:31:37Z","timestamp":1607013097000},"page":"362-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lymphoscintigraphic Bilateral Disease in Patients with Clinically Unilateral Primary Lower Limb Lymphedemas"],"prefix":"10.1177","volume":"19","author":[{"given":"Pierre","family":"Bourgeois","sequence":"first","affiliation":[{"name":"Services of Nuclear Medicine and of Dermatology, Multi-Disciplinary Clinic of Lymphology, Institute Jules Bordet, HIS-IZZ Hospitals and Universitary Hospital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"541","article-title":"Diagnosis and treatment of primary lymphedema. Consensus document of the international union of phlebology","volume":"32","author":"Lee BB","year":"2013","unstructured":"Lee BB, , Andrade M, , Antignani PL, , Boccardo F, , Bunke N, , Campisi C, , Damstra R, , Flour M, , Forner-Cordero I, , Gloviczki P, , Laredo J, , Partsch H, , Piller N, , Michelini S, , Mortimer P, , Rabe E, , Rockson S, , Scuderi A, , Szolnoky G, , Villavicencio JL. Diagnosis and treatment of primary lymphedema. Consensus document of the international union of phlebology. Int Angiol, 2013; 32:541\u2013574.","journal-title":"Int Angiol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1981.01380210037007"},{"key":"e_1_3_3_4_2","first-page":"344","article-title":"Fibrosis in the lymph nodes in primary lymphoedema. Histological and clinical studies in 74 patients with lower-limb oedema","volume":"62","author":"Kinmonth JB","year":"1980","unstructured":"Kinmonth JB, , Wolfe JH. Fibrosis in the lymph nodes in primary lymphoedema. Histological and clinical studies in 74 patients with lower-limb oedema. Ann R Coll Surg Engl, 1980; 62:344\u2013354.","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_3_3_5_2","first-page":"91","article-title":"Lymphoedema: Pathophysiology and classification","volume":"26","author":"Browse NL","year":"1985","unstructured":"Browse NL, , Stewart G. Lymphoedema: Pathophysiology and classification. J Cardiovasc Surg (Torino), 1985; 26:91\u2013106.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_3_6_2","volume-title":"Lymph Stasis: Pathophysiology, Diagnosis and Treatment","author":"Olszewski Wl","year":"1991","unstructured":"Olszewski Wl. Clinical picture of lymphedema. In: Olszewski WL, ed. Lymph Stasis: Pathophysiology, Diagnosis and Treatment. Florida: CRC Press, Inc., 1991:347\u2013379."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698748"},{"key":"e_1_3_3_8_2","unstructured":"Olszewski W. \u201cPathophysiological and clinical observations of obstructive lymphedema of the limbs\u201d in \u201cLymphedema.\u201d Clodius ed Georg Thieme Verlag Stuttgart 1977."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","unstructured":"Clodius L. \u201cLymphedema\u201d Clodius ed Georg Thieme Verlag Stuttgart 1977.","DOI":"10.1097\/00006534-197808000-00033"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1934.00160160125008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004518902"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0102"},{"key":"e_1_3_3_13_2","first-page":"1","article-title":"The diagnosis and treatment of peripheral lymphedema: 2016 Consensus Document of the International Society of Lymphology","volume":"46","author":"Executive Committee","year":"2016","unstructured":"Executive Committee. The diagnosis and treatment of peripheral lymphedema: 2016 Consensus Document of the International Society of Lymphology. Lymphology, 2016; 46:1\u201311.","journal-title":"Lymphology"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2020.0041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:13:16Z","timestamp":1777666396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2020.0041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["10.1089\/lrb.2020.0041"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2020.0041","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]}}}