{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:06:18Z","timestamp":1782770778314,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To examine the correlation between lymphedema severity on lymphoscintigraphy and indocyanine green (ICG) lymphography in patients with secondary lower extremity lymphedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      The maximal circumference difference (MCD) between the two legs was recorded. Lymphoscintigraphy and ICG lymphography images were classified into type I to V according to dermal backflow (DB) stage and MD Anderson Cancer Center (MDACC) stage based on lymphatic flow preservation and how DB was extended. Correlation between the scales was analyzed. Forty-four patients attended our hospital for evaluation of secondary lower extremity lymphedema. The most common cause of lymphedema was a postoperative complication of a malignant tumor (32 patients; 72.5%). Correlation analysis showed that lymphoscintigraphy and ICG DB (anterior) stage (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.92), lymphoscintigraphy and ICG DB (posterior) stage (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.94), and lymphoscintigraphy and MDACC stage (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.93) exhibited very strong positive correlations. Intrarater agreement between lymphoscintigraphy and ICG DB (posterior) stage was substantial (\n                      <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                      \u2009=\u20090.65), and moderate between lymphoscintigraphy and ICG DB (anterior) stage (\n                      <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                      \u2009=\u20090.59) and lymphoscintigraphy and MDACC stage (\n                      <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                      \u2009=\u20090.52). Lymphedema severity stages and MCDs exhibited moderate positive correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lymphoscintigraphy and ICG lymphography stage were strongly and positively correlated. These studies can work synergistically as complementary studies of lymphedema severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0043","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T18:04:05Z","timestamp":1595959445000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Indocyanine Green Lymphography and Lymphoscintigraphy Severity Stage Showed Strong Correlation in Lower Limb Lymphedema"],"prefix":"10.1177","volume":"19","author":[{"given":"Jin A","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Jun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Hyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Busan Cancer Center, Pusan National University Hospital and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.022"},{"key":"e_1_3_3_3_2","first-page":"43","article-title":"The third circulation: Radionuclide lymphoscintigraphy in the evaluation of lymphedema","volume":"44","author":"Szuba A","year":"2003","unstructured":"Szuba A, , Shin WS, , Strauss HW, , Rockson S. The third circulation: Radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med, 2003; 44:43\u201357.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.04.067"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200212000-00004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20772"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2545"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2017-4"},{"key":"e_1_3_3_9_2","first-page":"122","article-title":"New clinical and laboratory staging systems to improve management of chronic lymphedema","volume":"38","author":"Lee B","year":"2005","unstructured":"Lee B, , Bergan J. New clinical and laboratory staging systems to improve management of chronic lymphedema. Lymphology, 2005; 38:122\u2013129.","journal-title":"Lymphology"},{"key":"e_1_3_3_10_2","first-page":"79","article-title":"SPECT\u2013CT fusion imaging radionuclide lymphoscintigraphy: Potential for limb lymphedema assessment and sentinel node detection in breast cancer. In: Leong SP, ed. Cancer Metastasis and the Lymphovascular System: Basis for Rational Therapy","author":"Pecking AP","year":"2007","unstructured":"Pecking AP, , Wartski W, , Cluzan R, , Bellet D, , Alb\u00e9rini J. SPECT\u2013CT fusion imaging radionuclide lymphoscintigraphy: Potential for limb lymphedema assessment and sentinel node detection in breast cancer. In: Leong SP, ed. Cancer Metastasis and the Lymphovascular System: Basis for Rational Therapy. 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Relationship between lymphoscintigraphy and clinical findings in lower limb lymphedema (LO): Toward a comprehensive staging. 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