{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:21:07Z","timestamp":1780626067060,"version":"3.54.1"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sentinel lymph node biopsy (SLNB) is the accepted approach to stage the clinically negative axilla. The incidence of lymphedema (LE) after SLNB is about 5%. We hypothesize that patients undergoing axillary excision of &gt;5 lymph nodes (LNs) are at increased risk of developing LE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      A single institution prospective breast cancer database was retrospectively reviewed from January 2013 to December 2017, to identify patients who underwent SLNB and were diagnosed with LE. Inclusion criteria was (1)\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      breast cancer, (2) SLNB in clinically node negative patients, and (3) no preoperative diagnosis LE of an extremity. Exclusion criteria was history of axillary lymph node dissection. Age, body mass index, tumor\u2013node\u2013metastasis status, surgery type, neoadjuvant or adjuvant chemotherapy, radiotherapy, and hormone therapy were analyzed. Of the 3325 patients identified, 2940 patients met the inclusion criteria and were included in the final analysis. Median follow-up time was 24 months. Forty-seven (2%) patients were diagnosed with LE, and nine patients (19%) had &gt;5 LNs excised. LE was diagnosed in 3.7% of patients who had &gt;5 LNs excised versus 1.4% of patients with \u22645 LNs excised. Incidence of LE was higher in patients with &gt;5 LNs excision (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study showed that patients have a higher likelihood of developing LE when &gt;5 LNs are excised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0093","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T15:53:55Z","timestamp":1625068435000},"page":"160-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Lymphedema After Sentinel Lymph Node Biopsy: Who Is at Risk?"],"prefix":"10.1177","volume":"20","author":[{"given":"Arda","family":"Isik","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Soran","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Grasi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noran","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efe","family":"Sezgin","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Laboratory of Nutrigenomics and Epidemiology, Izmir Institute of Technology, Urla, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.12.041"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1688-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2856-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj158"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2846-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.04.011"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.232"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1089-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11470"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4062"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70460-7"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2016.10.083"},{"key":"e_1_3_4_15_2","first-page":"51","article-title":"Lymphedema: From diagnosis to treatment","volume":"33","author":"Kay\u0131ran O","year":"2017","unstructured":"Kay\u0131ran O, , De La Cruz C, , Tane K, , Soran A. Lymphedema: From diagnosis to treatment. 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