{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:50:03Z","timestamp":1785343803532,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Of the 1.38 million women who are diagnosed every year with breast cancer worldwide, 21% will develop arm lymphedema. Near-infrared fluorescence lymphatic imaging (NIRFLI) is an effective method for real-time evaluation of the lymphatic system. Reliability studies of the scoring of this NIRFLI are lacking. The aim of this study is to investigate if evaluation of the superficial lymphatic architecture and transport in patients with breast cancer-related lymphedema through NIRFLI can be performed in a reliable way.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      The outcome parameters used to assess agreement were the presence of lymphatic transport from the injection sites, of dermal backflow patterns, of efferent lymphatic vessels, and of lymph nodes. The NIRFLI evaluations were scored before and after a break separately by two assessors. Twenty patients with lymphedema of the arm and\/or hand were included. After the injection, there was weak to very strong agreement regarding the presence of transport from the injection sites (\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      \u2009=\u20090.459\u20131.000). The interpretation of the type of dermal backflow pattern varied from weak (WK\u2009=\u20090.452) to very strong agreement (WK\u2009=\u20091.000) between the two assessors. Agreement in the visualization of efferent lymphatic vessels was weak before and after the break (\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      \u2009=\u20090.490 and\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      \u2009=\u20090.571) and agreement regarding the presence of lymph nodes was very strong (\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      \u2009=\u20091.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Overall, there was moderate to strong agreement between the assessors when evaluating the lymphatic architecture and transport through NIRFLI.<\/jats:p>\n                    <jats:p>\n                      The study has been registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (NCT02609724).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0105","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T17:31:35Z","timestamp":1622655095000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Interrater Reliability of the Scoring of the Lymphatic Architecture and Transport Through Near-InfraRed Fluorescence Lymphatic Imaging in Patients with Breast Cancer-Related Lymphedema"],"prefix":"10.1177","volume":"20","author":[{"given":"Sarah","family":"Thomis","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven\u2014University Hospitals Leuven, Leuven, Belgium."},{"name":"Research Unit Vascular Surgery, Department of Cardiovascular Sciences, KU Leuven\u2014University of Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Helberg","sequence":"additional","affiliation":[{"name":"Berekuyl Academy and European College of Decongestive Lymphatic Therapy, Harderwijk, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jantine","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Berekuyl Academy and European College of Decongestive Lymphatic Therapy, Harderwijk, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa De","family":"Vrieze","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven\u2014University of Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Kathleen","family":"Heroes","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven\u2014University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Fourneau","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven\u2014University Hospitals Leuven, Leuven, Belgium."},{"name":"Research Unit Vascular Surgery, Department of Cardiovascular Sciences, KU Leuven\u2014University of Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Devoogdt","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven\u2014University Hospitals Leuven, Leuven, Belgium."},{"name":"Department of Rehabilitation Sciences, KU Leuven\u2014University of Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-098285"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq721"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/NJH.0b013e318236de5c"},{"key":"e_1_3_5_5_2","first-page":"3","article-title":"The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology","volume":"53","author":"International Society of Lymphology","year":"2020","unstructured":"International Society of Lymphology. The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology. Lymphology, 2020; 53:3\u201319.","journal-title":"Lymphology"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.06.006"},{"key":"e_1_3_5_7_2","first-page":"12","article-title":"Diagnosis and staging of lymphedema","author":"Greene EK","year":"2018","unstructured":"Greene EK, , Gross JA. Diagnosis and staging of lymphedema. Semin Plast Surg, 2018; :12\u201316.","journal-title":"Semin Plast Surg"},{"key":"e_1_3_5_8_2","first-page":"1","article-title":"False-negative tests","volume":"5","author":"Hassanein AH","year":"2017","unstructured":"Hassanein AH, , Maclellan RA, , Grant FD, , Green AK. False-negative tests. Plast Reconstr Surg Glob Open, 2017; 5:1\u20134.","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2016.10.083"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.116"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038182"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2015.0040"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2009.01.009"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182268cd9"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.02.023"},{"key":"e_1_3_5_16_2","first-page":"066019","article-title":"Sensitivity analysis of near-infrared functional lymphatic imaging","volume":"17","author":"Weiler M","year":"2012","unstructured":"Weiler M, , Kassis T, , Dixon JB. Sensitivity analysis of near-infrared functional lymphatic imaging. J Opt Med, 2012; 17:066019.","journal-title":"J Opt Med"},{"key":"e_1_3_5_17_2","first-page":"72","article-title":"Indocyanine green lymphography findings in limb lymphedema","volume":"32","author":"Narushima M","year":"2016","unstructured":"Narushima M, , Yamamoto T, , Ogata F, , Yoshimatsu H, , Mihara M, , Koshima I. Indocyanine green lymphography findings in limb lymphedema. J Reconstr Microsurg, 2016; 32:72\u201379.","journal-title":"J Reconstr Microsurg"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.12.023"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.01.003"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1180"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0168"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0034"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2020.0105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2020.0105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:13:35Z","timestamp":1777666415000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2020.0105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,1]]}},"alternative-id":["10.1089\/lrb.2020.0105"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2020.0105","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}