{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:57:35Z","timestamp":1789073855647,"version":"build-2803163510"},"reference-count":65,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Adipose tissue deposition is a known consequence of lymphedema. A previous study showed that the affected arm in patients with nonpitting breast cancer-related lymphedema (BCRL) had a mean excess volume of 73% fat and 47% muscle. This condition impairs combined physiotherapy as well as more advanced microsurgical methods. Liposuction is, therefore, a way of improving the effects of treatment. This study aims to evaluate the tissue changes in lymphedematous arms after liposuction and controlled compression therapy (CCT) in patients with nonpitting BCRL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Eighteen women with an age of 61 years and a duration of arm lymphedema (BCRL) of 9 years were treated with liposuction and CCT. Tissue composition of fat, lean (muscle), and bone mineral was analyzed through dual energy X-ray absorptiometry (DXA) before, and at 3 and 12 months after surgery. Excess volumes were also measured with plethysmography. The median DXA preoperative excess volume was 1425\u2009mL (704\u2009mL fat volume, 651\u2009mL lean volume). The DXA excess volume at 3 months after surgery was 193\u2009mL (\u2212196\u2009mL fat volume, 362\u2009mL lean volume). At 12 months after surgery, the median excess DXA volume was 2\u2009mL (\u2212269\u2009mL fat volume, 338\u2009mL lean volume). From before surgery to 3 months after surgery, the median DXA excess volume reduced by 85% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) (fat volume reduction 128% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lean volume reduction 37% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.016)). From before surgery to 12 months after surgery, it reduced by 100% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) (fat volume reduction 139% [\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001], lean volume reduction 54% [\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0013]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Liposuction and CCT effectively remove the excess fat in patients with nonpitting BCRL, and a total reduction of excess arm volume is achievable. A postoperative decrease in excess muscle volume is also seen, probably due to the reduced weight of the arm postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2020.0120","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T10:53:25Z","timestamp":1614768805000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Liposuction of Breast Cancer-Related Arm Lymphedema Reduces Fat and Muscle Hypertrophy"],"prefix":"10.1177","volume":"20","author":[{"given":"Tobias","family":"Karlsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden."},{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Ohlin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaby","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Brorson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden."},{"name":"Department of Plastic and Reconstructive Surgery, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5960-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.05.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.12338"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.04.011"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0042"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450b2d"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450b47"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2008.1022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24972"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2006.4404"},{"key":"e_1_3_3_13_2","first-page":"175","article-title":"The pitting test; an investigation of an unstandardized assessment of lymphedema","volume":"48","author":"Sanderson J","year":"2015","unstructured":"Sanderson J, , Tuttle N, , Box R, , Reul-Hirche HM, , Laakso EL. 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