{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:31:34Z","timestamp":1792272694841,"version":"4.4.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer survivors who report chronic pain in the affected ipsilateral upper limb or body are nearly twice as likely to develop lymphedema. Little is known about lymphatic pain, defined as co-occurring pain and swelling in the affected ipsilateral upper limb or body. The study aimed to examine the predictors and effects of lymphatic pain on breast cancer survivors' activities of daily living (ADLs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A sample of 568 patients was recruited in a metropolitan cancer center in the United States. Demographic and clinical data were collected. Body mass index (BMI) and limb volume were measured using infra-red perometer. Lymphatic pain and ADLs were measured by the Lymphedema and Breast Cancer Symptom Experience Index. Parametric and nonparametric tests and generalized linear models were used to analyze data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Lymphatic pain affected 33% of survivors. Significant predictors of lymphatic pain included younger age, higher BMI, financial hardship, and a diagnosis of lymphedema. Patients with a diagnosis of lymphedema had 9.68 odds (confidence interval [CI]: 5.78\u201316.63;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and those with financial hardship had 4.64 odds (CI: 1.99\u201311.32;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) of experiencing lymphatic pain. Patients with lymphatic pain had more impairments in ADLs (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to patients with only pain, only swelling, and no symptoms. Significantly more patients with lymphatic pain had a limb volume difference of &gt;5% and &gt;10% compared to patients with only pain and no symptom.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study is the first to report that in a large sample of patients, 33.1% experienced lymphatic pain and that lymphatic pain was associated with significant impairments in ADLs. Findings suggest that lymphatic pain may be due to abnormal accumulation of lymph fluid. Research is needed to ascertain the physiological mechanisms that underlie lymphatic pain and determine whether strategies to prevent and treat lymphedema can decrease lymphatic pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2021.0017","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:28:53Z","timestamp":1770290933000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphatic Pain in Breast Cancer Survivors"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-8394","authenticated-orcid":false,"given":"Katie","family":"Fitzgerald Jones","sequence":"first","affiliation":[{"name":"Boston College, William F. Connell School of Nursing, Chestnut Hill, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-0109","authenticated-orcid":false,"given":"Mei Rosemary","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Nursing\u2013Camden, Rutgers University, Camden, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-8307","authenticated-orcid":false,"given":"Melissa L.","family":"McTernan","sequence":"additional","affiliation":[{"name":"Boston College, Chestnut Hill, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-0639","authenticated-orcid":false,"given":"Eunjung","family":"Ko","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Nursing, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6621-6638","authenticated-orcid":false,"given":"Simay","family":"Yazicioglu","sequence":"additional","affiliation":[{"name":"New York University Tandon School of Engineering, Brooklyn, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9929-3389","authenticated-orcid":false,"given":"Deborah","family":"Axelrod","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York University School of Medicine, NYU Perlmutter Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-4089","authenticated-orcid":false,"given":"Amber A.","family":"Guth","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York University School of Medicine, NYU Perlmutter Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Miaskowski","sequence":"additional","affiliation":[{"name":"Departments of Physiological Nursing and Anesthesia and Perioperative Care, University of California, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette P.","family":"Conley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Boston College, William F. Connell School of Nursing, Chestnut Hill, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-3802","authenticated-orcid":false,"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering and Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-30"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.04.030"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3201"},{"key":"e_1_3_6_5_2","unstructured":"Breast Cancer Facts & Figures 2019\u20132020. Atlanta: American Cancer Society https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/breast-cancer-facts-and-figures\/breast-cancer-facts-and-figures-2019-2020.pdf Accessed June18 2020."},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4670-9"},{"key":"e_1_3_6_7_2","first-page":"345","article-title":"Symptom reporting in detecting breast cancer-related lymphedema","volume":"7","author":"Fu MR","year":"2015","unstructured":"Fu MR, , Axelrod D, , Cleland CM, et al. Symptom reporting in detecting breast cancer-related lymphedema. Breast Cancer (Dove Med Press), 2015; 7:345\u2013352.","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2008.1026"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12609-020-00397-6"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.06.023"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.08.105"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5206"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0452-2"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0168"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0b013e31818c3de2"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.12.006"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200311000-00004"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5206"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.07.006"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.21037\/mhealth.2016.07.03"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.05.002"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0941-3"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0077"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2005.3.208"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj130"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3325-3"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200505000-00007"},{"key":"e_1_3_6_29_2","first-page":"161","article-title":"Minimal limb volume change has a significant impact on breast cancer survivors","volume":"42","author":"Cormier JN","year":"2009","unstructured":"Cormier JN, , Xing Y, , Zaniletti I, , Askew RL, , Stewart BR, , Armer JM. Minimal limb volume change has a significant impact on breast cancer survivors. Lymphology, 2009; 42:161\u2013175.","journal-title":"Lymphology"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0033"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1439"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8241710"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04804-2"},{"key":"e_1_3_6_34_2","first-page":"30","article-title":"Women at work with breast cancer-related lympheodema","volume":"3","author":"Fu MR","year":"2008","unstructured":"Fu MR. Women at work with breast cancer-related lympheodema. J Lymphedema, 2008; 3:30\u201336.","journal-title":"J Lymphedema"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2021.0017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2021.0017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2021.0017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:29:10Z","timestamp":1773246550000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2021.0017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1089\/lrb.2021.0017"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2021.0017","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}