{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:01:23Z","timestamp":1791442883269,"version":"4.3.3"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recent advances in technology have allowed intermittent pneumatic compression (IPC) devices to develop so that their function mimics the process and principles of manual lymphatic drainage (MLD); however, research into the effectiveness of such devices is lacking. This study aimed to investigate the effectiveness of a patented IPC technique designed to mimic MLD (the LymphAssist), compared with a typical sequential IPC regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Forty patients with a confirmed diagnosis of lower limb ISL (International Society of Lymphology) stage II or III lymphedema were recruited into this three-phased study. A bilateral leg volume assessment and quality-of-life assessment were completed at four clinic visits across the course of the study. The LymphAssist IPC regimen was significantly more effective in reducing distal leg volume than the sequential mode (mean volume reduction: 230\u2009\u00b1\u2009135\u2009mL vs. 140\u2009\u00b1\u200984\u2009mL, respectively,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01). Improvements in leg volume were transient as both groups demonstrated a rebound or increase in volume during the washout period (LymphAssist: 238\u2009\u00b1\u2009168\u2009mL, sequential: 276\u2009\u00b1\u2009158\u2009mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.3). Overall, IPC was effective in improving quality-of-life scores (mean reduction: 10\u2009\u00b1\u200911,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IPC is effective in reducing limb volume and improving quality of life for patients with lower limb lymphedema. IPC that mimics the MLD process has been shown to be more effective in reducing leg volume compared with traditional sequential IPC in the distal aspect of the leg. The increase in leg volume observed after discontinuation of IPC suggests that regular treatment is required to maintain its associated effects.<\/jats:p>\n                    <jats:p>Clinical Trial Registration Number: NTC 03856281.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2021.0025","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T17:07:11Z","timestamp":1639069631000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Intermittent Pneumatic Compression for the Treatment of Lower Limb Lymphedema: A Pilot Trial of Sequencing to Mimic Manual Lymphatic Drainage Versus Traditional Graduated Sequential Compression"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-935X","authenticated-orcid":false,"given":"Nyree","family":"Dunn","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences, University of South Wales, Pontypridd, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of South Wales, Pontypridd, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Dolan","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of South Wales, Pontypridd, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane H.","family":"Davies","sequence":"additional","affiliation":[{"name":"Huntleigh Healthcare, Cardiff, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"24","article-title":"Redefining essential care in lymphoedema","volume":"20","author":"Wigg J","year":"2014","unstructured":"Wigg J, , Lee N. Redefining essential care in lymphoedema. Br J Community Nurs, 2014; 20:24\u201327.","journal-title":"Br J Community Nurs"},{"key":"e_1_3_5_3_2","first-page":"13","article-title":"Intermittent pneumatic compression therapy: A systematic review","volume":"45","author":"Feldmen JL","year":"2012","unstructured":"Feldmen JL, , Stout NL, , Wanchai A, , Stewart BR, , Cormier JN, , Armer JN. Intermittent pneumatic compression therapy: A systematic review. Lymphology, 2012; 45:13\u201325.","journal-title":"Lymphology"},{"key":"e_1_3_5_4_2","first-page":"1545","article-title":"Comparison of efficacy of the intermittent pneumatic compression with a high-and-low pressure application in reducing the lower limbs phlebolymphedema","volume":"11","author":"Taradaj J","year":"2015","unstructured":"Taradaj J, , Rosinczuk J, , Dymarek R, , Halski T, , Schneider W. Comparison of efficacy of the intermittent pneumatic compression with a high-and-low pressure application in reducing the lower limbs phlebolymphedema. Ther Clin Risk Manag, 2015; 11:1545\u20131554.","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10976"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-84"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1188\/08.ONF.671-680"},{"key":"e_1_3_5_8_2","first-page":"3279","article-title":"A randomized controlled trial comparing two types of pneumatic compression for breast cancer-related lymphedema treatment in the home","volume":"20","author":"Fife CE","year":"2012","unstructured":"Fife CE, , Davey S, , Maus EA, , Guilliod R, , Mayrovitz HN. A randomized controlled trial comparing two types of pneumatic compression for breast cancer-related lymphedema treatment in the home. Support Cancer Care, 2012; 20:3279\u20133286.","journal-title":"Support Cancer Care"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12060"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-010-0006-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2016.21.Sup10.S13"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.07.012"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-019-0496-4"},{"key":"e_1_3_5_14_2","unstructured":"Lymphoedema Framework. Best practice management of lymphoedema. 2006. Available at: https:\/\/tinyurl.com\/y8hhd66c (accessed September27 2021)."},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8010015"},{"key":"e_1_3_5_16_2","first-page":"27","article-title":"Measuring change in limb volume to evaluate lymphoedema treatment outcome","volume":"15","author":"Williams AF","year":"2015","unstructured":"Williams AF, , Whitaker J. Measuring change in limb volume to evaluate lymphoedema treatment outcome. EWMA J, 2015; 15:27\u201332.","journal-title":"EWMA J"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20130285"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0033"},{"key":"e_1_3_5_19_2","volume-title":"Intermittent Pneumatic Compression Devices for the Management of Lymphedema: A Review of Clinical Effectiveness and Guidelines","author":"Tran K","year":"2012","unstructured":"Tran K, , Argaez C. Intermittent Pneumatic Compression Devices for the Management of Lymphedema: A Review of Clinical Effectiveness and Guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2012."},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)83188-5"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12648"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3201"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2015.07.004"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2011.13.2\/npatsopoulos"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2021.0025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2021.0025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2021.0025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:00Z","timestamp":1777666440000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2021.0025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1089\/lrb.2021.0025"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2021.0025","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}