{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:43:44Z","timestamp":1793774624406,"version":"4.6.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study compared rates of progression to chronic breast cancer-related lymphedema (defined as \u2265\u200910% arm volume change from baseline requiring complex decongestive physiotherapy [CDP]) following an intervention for subclinical lymphedema (S-BCRL) triggered by bioimpedance spectroscopy (BIS) or by tape measurement (TM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      This stratified, randomized, international trial enrolled new breast cancer patients undergoing: mastectomy\/partial mastectomy, axillary treatment (dissection, sentinel lymph node biopsy [SLNB] &gt;6 nodes or radiation), radiation therapy (chest wall\/breast, supraclavicular fossa), or taxane-based chemotherapy. Following postsurgery eligibility reassessment, centralized, 1:1 randomization to prospective surveillance by BIS or TM occurred. S-BCRL detection triggered a 4-week, 12-hour per day, compression sleeve, and gauntlet intervention. The primary outcome (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009209), rates of postintervention progression to CDP, was assessed over 3 years. Between June 24, 2014 and September 11, 2018, 1200 patients were enrolled, 963 randomized (BIS\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009482; TM\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009481) and 879 analyzed (BIS\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009442; TM\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009437). Median follow-up was 32.9 months (interquartile range\u2009=\u200922, 35). BIS patients triggered an intervention at a lower rate than TM patients (20.1%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200989 vs. 27.5%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009120,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011). Median months to trigger were longer with BIS than TM (9.7; 95% confidence interval [CI], 8.2\u201312.6 vs. 3.9; 95% CI, 2.8\u20134.5,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). Overall, 14.4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200930) progressed post-intervention, with reduced likelihood for BIS patients than TM patients (7.9%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20097 vs. 19.2%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200923; relative risk\u2009=\u20090.41; 95% CI, 0.13\u20130.81; absolute reduction 11.3%; 95% CI, 2.3\u201320.3;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Compared to TM, BIS provides a more precise identification of patients likely to benefit from an early compression intervention.<\/jats:p>\n                    <jats:p>Clinical Trial Registration number: NCT02167659.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2021.0084","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T10:11:50Z","timestamp":1643623910000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["A Comparison of Bioimpedance Spectroscopy or Tape Measure Triggered Compression Intervention in Chronic Breast Cancer Lymphedema Prevention"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-7405","authenticated-orcid":false,"given":"Sheila H.","family":"Ridner","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Nursing, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Nursing, Nashville, Tennessee, USA."},{"name":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-3966","authenticated-orcid":false,"given":"John","family":"Boyages","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research, and Treatment Program, Macquarie University, Macquarie Park, Australia."},{"name":"Department of Clinical Medicine, Macquarie University, Macquarie Park, Australia."},{"name":"Medicine, Health &amp; Human Sciences, ICON Cancer Center, Wahroonga, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Koelmeyer","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research, and Treatment Program, Macquarie University, Macquarie Park, Australia."},{"name":"Department of Clinical Medicine, Macquarie University, Macquarie Park, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Elder","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital, Westmead, Australia."},{"name":"The University of Sydney, Sydney, Australia."},{"name":"Lakeside Specialist Breast Clinic, Lakeview Private Hospital, Norwest, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-486X","authenticated-orcid":false,"given":"T. Michael","family":"Hughes","sequence":"additional","affiliation":[{"name":"Northern Surgical Oncology, Sydney Adventist Hospital, Wahroonga, Australia."},{"name":"Sydney Adventist Hospital Clinical School, College of Health and Medicine, Australian National University, Acton, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"French","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital, Westmead, Australia."},{"name":"The University of Sydney, Sydney, Australia."},{"name":"Lakeside Specialist Breast Clinic, Lakeview Private Hospital, Norwest, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ngui","sequence":"additional","affiliation":[{"name":"Northern Surgical Oncology, Sydney Adventist Hospital, Wahroonga, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Macquarie University, Macquarie Park, Australia."},{"name":"Westmead Breast Cancer Institute, Westmead Hospital, Westmead, Australia."},{"name":"The University of Sydney, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana G.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Moore","sequence":"additional","affiliation":[{"name":"Southeast Cancer Center, Cape Girardeau, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Shah","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"Breast Cancer Research Foundation. 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