{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:16:57Z","timestamp":1777922217626,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Methods of conservative management for breast cancer-related lymphedema (BCRL) are burdensome in terms of time, cost, and convenience. In addition, many patients are not candidates for surgical treatment. Preliminary results have demonstrated possible beneficial effects of acupuncture for patients with BCRL. In this small pilot study, we examined the safety and feasibility of an acupuncture randomized control trial (RCT) in this patient cohort, utilizing a battery of standardized clinical and patient-centered outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Patients with BCRL were randomized 2:1 to the acupuncture (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910) or the control (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094) group. Patients received acupuncture to the unaffected extremity biweekly for 6 weeks. Feasibility was defined as enrollment \u226580%, completion of \u22659 of 12 acupuncture sessions per person, and \u226575% completion of three of three measurement visits. To inform a future adequately powered RCT, we describe within-group changes in patient-centered outcomes, including circumferential measurements, bioimpedance spectroscopy, perometry, cytokine levels, and patient quality of life. Adverse events were systematically tracked. Fourteen patients completed the study. Of those who received acupuncture (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910), 8 completed all 12 acupuncture sessions, and 2 patients completed 11 sessions. Ninety-three percent of all participants completed all three measurement visits. There was no consistent improvement in arm volumes. Inflammatory marker levels had inconclusive fluctuations among both groups. All patients receiving acupuncture demonstrated an improvement in their functional quality-of-life score. No severe adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A randomized controlled study of acupuncture for BCRL is feasible. The acupuncture intervention is acceptable in this population, without safety concerns in a small sample and warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0001","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T14:20:56Z","timestamp":1682086856000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acupuncture Treatment for Breast Cancer-Related Lymphedema: A Randomized Pilot Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Rosie","family":"Friedman","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rose","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Shillue","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Fleishman","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Mistretta","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Magrini","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao Ngoc N.","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley G.","family":"Rockson","sequence":"additional","affiliation":[{"name":"Stanford Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Y.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv","family":"Singhal","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3201"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4239"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143584"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.1132"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0870-5"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006223"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0098"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28093"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4743-9"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3747\/co.23.2788"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2018-011668"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2021.0133"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14122"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534735419866910"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","unstructured":"Brorson H Svensson B Ohlin K. (2015). Volume Measurements and Follow-Up. In: Lymphedema. (Greene A Slavin S Brorson H. eds.) Springer: Cham; doi: 10.1007\/978-3-319-14493-1_11","DOI":"10.1007\/978-3-319-14493-1_11"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357900902918494"},{"issue":"1","key":"e_1_3_5_20_2","first-page":"26","article-title":"A quality of life measure for limb lymphoedema (LYMQOL)","volume":"5","author":"Keeley V","year":"2010","unstructured":"Keeley V, , Crooks S, , Locke J, et al. A quality of life measure for limb lymphoedema (LYMQOL). J Lymphoedema, 2010; 5(1):26\u201337.","journal-title":"J Lymphoedema"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052021"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123775"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01203-2"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8413576"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1202263"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/975632"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2014-010593"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30447"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2022.0001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:32Z","timestamp":1777666472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2022.0001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1089\/lrb.2022.0001"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2022.0001","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]}}}