{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:03:29Z","timestamp":1791223409675,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"\n Background:<\/jats:title>\n Patients underwent a compression (sleeve and gauntlet) intervention for subclinical breast cancer-related lymphedema (S-BCRL). Physical, emotional, and quality-of-life (QoL) outcomes were examined. Associations of change in extracellular fluid alone through bioimpedance spectroscopy (BIS) or change in whole-arm volume through tape measure with the outcomes at time of S-BCRL were explored.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results:<\/jats:title>\n We enrolled newly diagnosed nonmetastatic breast cancer patients for surveillance up to 36 months postoperatively. Upon detection of S-BCRL, a 28-day compression intervention was initiated. Data were obtained through physical examination\/measurement and self-report instruments: skin examination, Lymphedema Symptom Intensity and Distress Survey-Arm, and Functional Assessment of Cancer Therapy General (FACT-G), Breast (FACT-B), and FACT-B+4.<\/jats:p>\n \n Improvements with intervention were observed in the proportion of patients reporting symptom scores \u22653 in function (Cohen's\n d<\/jats:italic>\n \u2009=\u2009\u22120.46,\n p<\/jats:italic>\n \u2009<\u20090.01), in biobehavioral (Cohen's\n d<\/jats:italic>\n \u2009=\u2009\u22120.30,\n p<\/jats:italic>\n \u2009<\u20090.05), maximum number of skin conditions (Cohen's\n d<\/jats:italic>\n \u2009=\u2009\u22120.34,\n p<\/jats:italic>\n \u2009<\u20090.05. 3), FACT-B (Cohen's\n d<\/jats:italic>\n \u2009=\u20090.52,\n p<\/jats:italic>\n \u2009<\u20090.01), and FACT-B + four (Cohen's\n d<\/jats:italic>\n \u2009=\u2009\u22120.42,\n p<\/jats:italic>\n \u2009<\u20090.01). At the study endpoint, compared with those who did not progress, chronic breast cancer-related lymphedema (C-BCRL) progressing patients had higher overall symptom scores (\n p<\/jats:italic>\n \u2009=\u20090.037), more skin conditions (\n p<\/jats:italic>\n \u2009=\u20090.009), and lower total FACT-G and FACT-B scores (\n p<\/jats:italic>\n \u2009<\u20090.05). At the time of S-BCRL, detection of greater BIS unit change correlated with higher symptom, skin condition, and QoL values. Greater whole-arm volume change correlated with higher FACT-B+4 scores (all\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Prospective surveillance, symptom assessment, and compression intervention promote low progression rates from S-BCRL to C-BCRL and as such reduce symptom burden. This closed study is registered with\n ClinicalTrials.gov<\/jats:ext-link>\n NCT02167659\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/lrb.2022.0020","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:15:17Z","timestamp":1663694117000},"page":"304-313","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prospective Surveillance with Compression for Subclinical Lymphedema: Symptoms, Skin, and Quality-of-Life Outcomes"],"prefix":"10.1177","volume":"21","author":[{"given":"Mary S.","family":"Dietrich","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Nursing, Nashville, Tennessee, USA."},{"name":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Gaitatzis","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Koelmeyer","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-3966","authenticated-orcid":false,"given":"John","family":"Boyages","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia."},{"name":"Sydney Adventist Hospital Integrated Cancer Centre, ICON Cancer Centre, Wahroonga, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana G.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ngui","sequence":"additional","affiliation":[{"name":"Northern Surgical Oncology, Sydney Adventist Hospital, Wahroonga, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Elder","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Center Institute, Westmead Hospital, Westmead, Australia."},{"name":"Department of Surgery, The University of Sydney, Sydney, Australia."},{"name":"Lakeside Specialist Breast Clinic, Lakeview Private Hospital Norwest, Norwest, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"French","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Center Institute, Westmead Hospital, Westmead, Australia."},{"name":"Department of Surgery, The University of Sydney, Sydney, Australia."},{"name":"Lakeside Specialist Breast Clinic, Lakeview Private Hospital Norwest, Norwest, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hsu","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Center Institute, Westmead Hospital, Westmead, Australia."},{"name":"Department of Surgery, The University of Sydney, Sydney, Australia."},{"name":"Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michael","family":"Hughes","sequence":"additional","affiliation":[{"name":"Northern Surgical Oncology, Sydney Adventist Hospital, Wahroonga, Australia."},{"name":"Sydney Adventist Hospital Clinical School, College of Health and Medicine, Australian National University, Canberra, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deonni P.","family":"Stolldorf","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Nursing, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Shah","sequence":"additional","affiliation":[{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-7405","authenticated-orcid":false,"given":"Sheila H.","family":"Ridner","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Nursing, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.043"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2655-2"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0810-y"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2684-y"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000520501.23702.82"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.06.004"},{"key":"e_1_3_5_8_2","unstructured":"Stages of lymphedema. 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