{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:05:34Z","timestamp":1787508334798,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To analyze the factors influencing lower limb lymphedema (LLL) after cervical cancer surgery and provide a scientific reference for its effective prevention and control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Patients at a tertiary tumor hospital between January 2010 and January 2020 who received surgical treatment for cervical cancer were included in this study. Patients were divided into lymphedema case group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009253) and control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009506) according to lymphedema occurrence, and univariate and multivariate analyses were used to analyze the factors influencing the occurrence of LLL after cervical cancer surgery. Multifactor conditional logistic regression analysis revealed that risk factors for lymphedema occurrence included body mass index, level of education, the presence of preoperative radiotherapy and chemotherapy, radiotherapy within 3 months after postoperative chemoradiotherapy, emergence of coronary heart disease within 3 months, vaginal disease, occurrence of postoperative complications, cervical cancer diagnosis before the manifestation of menstrual abnormalities, and a history of previous surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Postoperative LLL after cervical cancer surgery is a chronic progressive disease, and no cure for LLL has been identified. Thus, determining the risk factors associated with LLL occurrence after uterine and cervical cancer surgery and the development of targeted prevention and early intervention strategies is urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0025","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T13:26:24Z","timestamp":1659101184000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors Influencing Lower Limb Lymphedema After Cervical Cancer Surgery: A Case\u2013Control Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Gaoming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Lymphedema Rehabilitation, Hunan Cancer Hospital\/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Lymphedema Rehabilitation, Hunan Cancer Hospital\/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Lymphedema Rehabilitation, Hunan Cancer Hospital\/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Lymphedema Rehabilitation, Hunan Cancer Hospital\/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.10.009"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.05.015"},{"key":"e_1_3_5_4_2","first-page":"1314","article-title":"Lower-extremity lymphedema in patients with cervical cancer after treatment","volume":"25","author":"Su W","year":"2018","unstructured":"Su W, , Liang Y, , Lu H, , Yang Y, , Zeng Y. Lower-extremity lymphedema in patients with cervical cancer after treatment. Chin J Clin Oncol Rehabil, 2018; 25:1314\u20131316.","journal-title":"Chin J Clin Oncol Rehabil"},{"key":"e_1_3_5_5_2","first-page":"222","article-title":"The research of incidence and mood disorders of lower limb lymphedema after cervical cancer operation","volume":"36","author":"Tuo S","year":"2015","unstructured":"Tuo S, , Lin R, , Luan H. The research of incidence and mood disorders of lower limb lymphedema after cervical cancer operation. Foreign Med Sci Sect Medgeogr, 2015; 36:222\u2013223.","journal-title":"Foreign Med Sci Sect Medgeogr"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-001032"},{"key":"e_1_3_5_7_2","volume-title":"Diagnosis and Treatment of Lymphedema","author":"Liu N","unstructured":"Liu N. Diagnosis and Treatment of Lymphedema. Science Press: Beijing; 2014."},{"key":"e_1_3_5_8_2","first-page":"355","article-title":"The Chinese consensus of the diagnosis and treatment of peripheral lymphedema","volume":"36","author":"The Chinese Society of Plastic Surgery Lymphedema Group","year":"2020","unstructured":"The Chinese Society of Plastic Surgery Lymphedema Group. The Chinese consensus of the diagnosis and treatment of peripheral lymphedema. Chin J Plast Surg, 2020; 36:355\u2013360.","journal-title":"Chin J Plast Surg"},{"key":"e_1_3_5_9_2","first-page":"311","article-title":"Research progress on evaluation methods of post-surgery lower limb lymphedema in patients with gynecological malignancies","volume":"52","author":"Wang X","year":"2017","unstructured":"Wang X, , Cai H, , Ding Y. Research progress on evaluation methods of post-surgery lower limb lymphedema in patients with gynecological malignancies. Chin J Nurs, 2017; 52:311\u2013315.","journal-title":"Chin J Nurs"},{"key":"e_1_3_5_10_2","first-page":"93","article-title":"The realization of N:M conditional logistic regression analysis in statistical software","volume":"28","author":"Zheng Y","year":"2011","unstructured":"Zheng Y, , Cao P, , Ou C. The realization of N:M conditional logistic regression analysis in statistical software. China Health Stat, 2011; 28:93\u201394,97.","journal-title":"China Health Stat"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182466950"},{"key":"e_1_3_5_12_2","first-page":"937","article-title":"Investigation on cognition of prevention and treatment of upper limb lymphedema in breast cancer patients after axillary dissection","volume":"38","author":"Li W","year":"2017","unstructured":"Li W, , Li X, , Zhou C, , Wu Y, , Ji X, , Fan Y. Investigation on cognition of prevention and treatment of upper limb lymphedema in breast cancer patients after axillary dissection. Guangdong Med J, 2017; 38:937\u2013940.","journal-title":"Guangdong Med J"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9021-y"},{"key":"e_1_3_5_14_2","first-page":"938","article-title":"Analysis of body mass index and prognosis of secondary lymphedema in lower extremities","volume":"40","author":"Su W","year":"2019","unstructured":"Su W, , Sun Y, , Xia S, , Xin J, , Chang K, , Shen W. Analysis of body mass index and prognosis of secondary lymphedema in lower extremities. J Cap Med Univ, 2019; 40:938\u2013942.","journal-title":"J Cap Med Univ"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.98"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1089-9"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02906.x"},{"key":"e_1_3_5_18_2","volume-title":"Risk Factors of Lymphedema of Lower Extremity After IB-IIA Cervical Cancer","author":"Gan F","year":"2020","unstructured":"Gan F. Risk Factors of Lymphedema of Lower Extremity After IB-IIA Cervical Cancer. Nanchang, China: Nanchang University; 2020."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000372"},{"key":"e_1_3_5_20_2","first-page":"282","article-title":"Research progress of early ambulation after surgery","volume":"23","author":"Zheng X","year":"2017","unstructured":"Zheng X, , Xing X, , Zhang S. Research progress of early ambulation after surgery. Chin J Modern Nurs, 2017; 23:282\u2013286.","journal-title":"Chin J Modern Nurs"},{"key":"e_1_3_5_21_2","first-page":"2219","article-title":"Research progress in risk factors and risk assessment of maternal deep vein thrombosis","volume":"24","author":"Liu Y","year":"2018","unstructured":"Liu Y, , Zhou Y, , Zhang L, et al. Research progress in risk factors and risk assessment of maternal deep vein thrombosis. Chin J Modern Nurs, 2018; 24:2219\u20132223.","journal-title":"Chin J Modern Nurs"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-008-1728-3"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13193"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2016.1247935"},{"key":"e_1_3_5_25_2","first-page":"843","article-title":"Prevention and management of lymphedema of lower extremity after pelvic lymphadenectomy","volume":"30","author":"Feng F","year":"2014","unstructured":"Feng F, , Xiang Y. Prevention and management of lymphedema of lower extremity after pelvic lymphadenectomy. Chin J Pract Gynecol Obst, 2014; 30:843\u2013846.","journal-title":"Chin J Pract Gynecol Obst"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0171-5"},{"key":"e_1_3_5_27_2","first-page":"108","article-title":"Analysis of lymphedema of lower extremity after cervical cancer treatment","volume":"25","author":"Kong X","year":"2015","unstructured":"Kong X, , Kong W. Analysis of lymphedema of lower extremity after cervical cancer treatment. J Pract Cancer, 2015; 25:108\u2013111.","journal-title":"J Pract Cancer"},{"key":"e_1_3_5_28_2","first-page":"498","article-title":"Risk factors of lymphedema of lower extremity after cervical cancer treatment: A Meta-analysis","volume":"34","author":"Deng Y","year":"2019","unstructured":"Deng Y. Risk factors of lymphedema of lower extremity after cervical cancer treatment: A Meta-analysis. J Adv Nurs, 2019; 34:498\u2013502.","journal-title":"J Adv Nurs"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2022.0025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:38Z","timestamp":1777666478000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2022.0025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["10.1089\/lrb.2022.0025"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2022.0025","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}