{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:16:58Z","timestamp":1777922218609,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The purpose of this study was to measure the effects of lymphoscintigraphically guided manual lymphatic drainage (LG-MLD) and to compare it with standardized manual lymphatic drainage (St-MLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Fifty-two patients with lymphedema of the upper limb who underwent lymphoscintigraphy were randomly allocated into two groups. Following the phase of physical activity, the control group underwent two phases of St-MLD as the experimental group underwent a first phase of St-MLD followed by a second phase of LG-MLD. Areas of interest were then selected [in particular, dermal backflow (DBF) and axillary lymph nodes (LN)], radioactive activities were quantified for each of these areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>If a first phase of St-MLD increased the LN activity by 28% on average, the findings indicated that for the second phase of DLM, LG-MLD was 19% more efficient than St-MLD in increasing LN activity. If a period of rest does not influence the lymph charge of DBF areas, physical activity leads to an average activity increase of 17%, whereas LG-MLD and St-MLD lead to an activity decrease of 11%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>For patients with lymphedema, the findings indicate that MLD can increase the lymphatic flow toward the lymphatic nodes by 28% on average and can decrease the charge in the areas of DBF by 11% on average. Moreover, lymphoscintigraphy can be an important therapeutic tool because LG-MLD significantly increases lymphatic flow by 19% more than St-MLD. Concerning the areas of DBF, the LG-MLD and St-MLD decrease the charge in these areas with the same intensity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0056","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:47:08Z","timestamp":1684338428000},"page":"594-600","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Lymphoscintigraphy as a Therapeutic Guidance Tool Can Improve Manual Lymphatic Drainage for the Physical Treatment of Patients with Upper Limb Lymphedema: Randomized Clinical Trial"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-2964","authenticated-orcid":false,"given":"Romain","family":"Barbieux","sequence":"first","affiliation":[{"name":"De Department of Nuclear Medicine and Multi-Disciplinary Clinic Unit of Lymphology, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium."},{"name":"Rehabilitation Sciences and Physiotherapy Faculty, Vrije Universiteit Brussel, Brussel, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Doyenard","sequence":"additional","affiliation":[{"name":"Lympho-Phlebology Unit, Department of Occupational and Environmental Physiology, Haute Ecole HE2B ISEK, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Pluska","sequence":"additional","affiliation":[{"name":"Lympho-Phlebology Unit, Department of Occupational and Environmental Physiology, Haute Ecole HE2B ISEK, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keoma","family":"Enciso","sequence":"additional","affiliation":[{"name":"Lympho-Phlebology Unit, Department of Occupational and Environmental Physiology, Haute Ecole HE2B ISEK, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela Mariana","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Mammo-Pelvic Surgery, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Leduc","sequence":"additional","affiliation":[{"name":"Lympho-Phlebology Unit, Department of Occupational and Environmental Physiology, Haute Ecole HE2B ISEK, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Leduc","sequence":"additional","affiliation":[{"name":"Physiotherapy and Rehabilitation Department, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-4334","authenticated-orcid":false,"given":"Pierre","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"De Department of Nuclear Medicine and Multi-Disciplinary Clinic Unit of Lymphology, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Provyn","sequence":"additional","affiliation":[{"name":"Anatomical Research and Clinical Studies, Vrije Universiteit Brussel, Brussel, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_3_6_2_2","first-page":"33","article-title":"Epidemiology and morbidity of Lymphoedema. 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