{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:16:55Z","timestamp":1777922215935,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The occurrence of breast cancer-related lymphedema (BCRL) in postoperative breast cancer survivors is described and the independent risk factors of BCRL are analyzed. A BCRL nomogram prediction model is constructed, and its effectiveness is evaluated to screen out high-risk patients with BCRL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A univariate analysis was carried out to determine the risk factors possibly related to BCRL, and a logistic regression analysis was utilized to determine the independent risk factors related to BCRL. A BCRL nomogram prediction model was built, and a nomogram was drawn by R software v4.1.0. The area under the curve (AUC) of the receiver operating characteristic (ROC) and the Hosmer\u2013Lemeshow test were used to evaluate the efficacy of the constructed model to assess its clinical application value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The risk factors independently associated with BCRL were body mass index (BMI), handedness on the operation side, no BCRL-related rehabilitation plan, axillary lymph node dissection (ALND), taxane-based chemotherapy, and radiotherapy (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The BCRL nomogram prediction model was built on this basis, and the results of the efficacy evaluation showed a good fit: AUC\u2009=\u20090.952 (95% confidence interval: 0.930\u20130.973) for the ROC and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20096.963,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.540 for the Hosmer\u2013Lemeshow test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The risk factors for BCRL included higher BMI, handedness on the operation side, no BCRL-related rehabilitation plan, ALND, taxane-based chemotherapy, and radiotherapy. In addition, the BCRL nomogram prediction model accurately calculated the risk of possible BCRL among breast cancer survivors and effectively screened for high-risk patients with BCRL. Therefore, this prediction model can provide a basis for rehabilitation physicians and therapists to formulate early and individualized prevention and treatment programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0058","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:23:06Z","timestamp":1695903786000},"page":"565-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of the Risk Factors of Breast Cancer-Related Lymphedema and Construction and Evaluation of a Prediction Model"],"prefix":"10.1177","volume":"21","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng-Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Heibei General Hospital, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Yuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Neurology, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."},{"name":"Department of Rehabilitation, Heibei General Hospital, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Biao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hebei Medical University, Heibei, China."},{"name":"Department of Rehabilitation, Heibei General Hospital, Heibei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"issue":"3","key":"e_1_3_8_2_2","first-page":"2085","article-title":"Lymphedema in survivors of breast cancer","volume":"19","author":"He L","year":"2020","unstructured":"He L, , Qu H, , Wu Q, , Song Y. Lymphedema in survivors of breast cancer. Oncol Lett, 2020; 19(3):2085\u20132096; doi: 10.3892\/ol.2020.11307.","journal-title":"Oncol Lett"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.06.004"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-021-00276-y"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89055-0"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-021-01762-9"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.08.036"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.12.009"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.03.44"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.08.008"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-021-01263-8"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.15761\/CRT.1000293"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31828d7285"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2655-2"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0059"},{"issue":"3","key":"e_1_3_8_16_2","first-page":"991","article-title":"Risk factors and prediction model for persistent breast-cancer-related lymphedema: A 5-year cohort study","volume":"27","author":"Penn IW","year":"2019","unstructured":"Penn IW, , Chang YC, , Chuang E, et al. Risk factors and prediction model for persistent breast-cancer-related lymphedema: A 5-year cohort study. Support Care Cancer, 2019; 27(3):991\u20131000; doi: 10.1007\/s00520-018-4388-6.","journal-title":"Support Care Cancer"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000468"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443491"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0448"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12466"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30204-2"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0083"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06507-x"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.10.024"},{"issue":"3","key":"e_1_3_8_25_2","first-page":"255","article-title":"Comparison between the effectiveness of complex decongestive therapy and stellate ganglion block in patients with breast cancer-related lymphedema: A randomized controlled study","volume":"22","author":"Park MW","year":"2019","unstructured":"Park MW, , Lee SU, , Kwon S, , Seo KS. Comparison between the effectiveness of complex decongestive therapy and stellate ganglion block in patients with breast cancer-related lymphedema: A randomized controlled study. Pain Physician, 2019; 22(3):255\u2013263.","journal-title":"Pain Physician"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00459"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878708"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0097"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.230"},{"issue":"10","key":"e_1_3_8_30_2","first-page":"954","article-title":"Guidelines and Specifications for diagnosis and Treatment of Breast Cancer of The Chinese Anti-Cancer Association (2021 edition) (2021)","volume":"31","author":"Breast Cancer Professional Committee of Chinese Anti-Cancer Society","year":"2021","unstructured":"Breast Cancer Professional Committee of Chinese Anti-Cancer Society. Guidelines and Specifications for diagnosis and Treatment of Breast Cancer of The Chinese Anti-Cancer Association (2021 edition) (2021). China Oncol, 2021; 31(10):954\u20131040; doi: 10.19401\/j.cnki.1007-3639.2021.10.013.","journal-title":"China Oncol"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31873"},{"issue":"23","key":"e_1_3_8_32_2","first-page":"5","article-title":"Risk factors and nursing intervention of postoperative lymphedema in patients undergoing breast cancer operation","volume":"17","author":"Zhang GT","year":"2020","unstructured":"Zhang GT. Risk factors and nursing intervention of postoperative lymphedema in patients undergoing breast cancer operation. Nurs Pract Res, 2020; 17(23):5\u20138; doi: 10.3969\/j.issn.1672-9676.2020.23.002.","journal-title":"Nurs Pract Res"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.5606\/tftrd.2021.5022"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0870-5"},{"key":"e_1_3_8_35_2","first-page":"3806150","article-title":"Healthcare practitioners' knowledge of lymphedema","volume":"2021","author":"Yarmohammadi H","year":"2021","unstructured":"Yarmohammadi H, , Rooddehghan A, , Soltanipur M, et al. Healthcare practitioners' knowledge of lymphedema. Int J Vasc Med, 2021; 2021:3806150; doi: 10.1155\/2021\/3806150.","journal-title":"Int J Vasc Med"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/0193945917744351"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100875"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2290-x"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.11.009"},{"issue":"01","key":"e_1_3_8_40_2","first-page":"53","article-title":"Clinical study on risk prediction of postoperative lymphedema in breast cancer patients after breast-preserving surgery based on Bevilacqua mode","volume":"15","author":"Du Y","year":"2021","unstructured":"Du Y, , Guan X, , Chang D, et al. Clinical study on risk prediction of postoperative lymphedema in breast cancer patients after breast-preserving surgery based on Bevilacqua mode. Chinese J Gen Surg, 2021; 15(01):53\u201356; doi: 10.3877\/cma.j.issn.1674-3946.2021.01.016.","journal-title":"Chinese J Gen Surg"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003491"},{"key":"e_1_3_8_42_2","unstructured":"Dou WJ. Construction and Evaluation of a Predictive Model for Upper Limb Lymphedema Associated with Breast Cancer. Anhui Medical University; 2016."},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5600804"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2022.0058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2022.0058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:44Z","timestamp":1777666484000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2022.0058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12,1]]}},"alternative-id":["10.1089\/lrb.2022.0058"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2022.0058","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]}}}