{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:54:08Z","timestamp":1788666848766,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To explore the effect of manual lymph drainage (MLD), compression bandaging (CB), or combined decongestive therapy (CDT), including MLD and CB, on stage 2 breast cancer-related lymphedema (BCRL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty women with stage 2 BCRL were enrolled. They were randomly divided into the MLD group, the CB group or the CDT group. Each group, respectively, received MLD alone, CB alone, or CDT composed of MLD and CB, for 2 weeks. The volume and the local tissue water (LTW) of affected arms were measured before and after treatment. Arm circumferences were measured at 4\u2009cm interval starting from the wrist to the shoulder with a tape measure. LTW was detected using the (tissue dielectric constant, TDC) method and was expressed as TDC value in two sites on the ventral midpoint of upper arm and forearm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The volume of affected arms in each group after 2-weeks' treatment was lower than their baseline and the difference was statistically significant (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). But there was no significant difference in volume change among three groups. The TDC value of the upper arm and forearm in the group CB and the group CDT decreased distinctly compared with baseline (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). But the TDC value of the upper arm and forearm after MLD did not change (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Compared with the group MLD and the group CDT, the reduction of the TDC value in the group CB was more significant (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MLD or CB alone could effectively reduce the volume of affected arms for patients with stage 2 BCRL, and CB also could reduce the LTW more significantly. CDT did not seem to show an extra advantage. Therefore, CB may be the first choice for stage 2 BCRL. But for patients who are unwilling or intolerant to CB, MLD can be selected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0074","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:45:14Z","timestamp":1683197114000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Manual Lymph Drainage and Compression Bandaging for Stage 2 Breast Cancer-Related Lymphedema: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"21","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wowa","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-8038","authenticated-orcid":false,"given":"Jinghong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"2085","article-title":"Lymphedema in survivors of breast cancer","volume":"19","author":"He L","year":"2020","unstructured":"He L, , Qu H, , Wu Q, et al. Lymphedema in survivors of breast cancer. Oncol Lett, 2020; 19:2085\u20132096.","journal-title":"Oncol Lett"},{"key":"e_1_3_5_3_2","first-page":"3805","article-title":"Combined decongestive therapy and reduction of pain and heaviness in patients with breast cancer-related lymphedema","volume":"27","author":"Mobarakeh ZS","year":"2019","unstructured":"Mobarakeh ZS, , Mokhtari-Hesari P, , Lotfi-Tokaldany M, et al. Combined decongestive therapy and reduction of pain and heaviness in patients with breast cancer-related lymphedema. 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