{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:17:02Z","timestamp":1777922222997,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer-related lymphedema (BCRL) is a debilitating chronic illness. Early management and prevention of disease progression rely on lymphedema monitoring and assessment. At present, lymphedema monitoring systems are costly and do not promote remote monitoring. Thus, a low-cost, portable, mobile-based bioimpedance lymphedema monitoring system (Mobilymph) was developed to ensure continuous lymphedema surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and Results:<\/jats:title>\n                    <jats:p>\n                      Forty-five healthy and 100 BCRL participants were recruited in this study. Mobilymph bioimpedance measurement was validated with a Quadscan 4000 on healthy participants' arms. The interarm bioimpedance ratio was determined to evaluate the discriminatory capability of Mobilymph to detect BCRL. Mobilymph's bioimpedance results show no significant difference compared to Quadscan 4000. The interarm bioimpedance ratios were significantly different (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), between participants in healthy and Stage 1, Stage 0 and Stage 1, and Stage 1 and Stage 2. Healthy and Stage 0 participants had similar interarm impedance ratios (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The bioimpedance results show that Mobilymph bioimpedance measurement is comparable to Quadscan 4000 and can detect BCRL arms. Thus, Mobilymph lymphedema monitoring system offers a feasible solution for early lymphedema diagnosis and treatment monitoring.<\/jats:p>\n                    <jats:p>Clinical trial registration number: MREC ID No.: 2020316-8181<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2022.0102","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T09:52:46Z","timestamp":1682329966000},"page":"463-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Low-Cost, Portable, and Mobile-Based Bioimpedance Lymphedema Diagnosis and Monitoring System (Mobilymph): A Validation Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Syarifah Aisyah","family":"Syed Ibrahim","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-4362","authenticated-orcid":false,"given":"Fatimah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Centre for Innovation in Medical Engineering, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Aishah Mohd","family":"Taib","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongman","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Inje University, Gimhae, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-018-0830-3"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6601-8"},{"issue":"12","key":"e_1_3_5_4_2","first-page":"1277","article-title":"Management of secondary lymphedema related to breast cancer","volume":"56","author":"Cheifetz O","year":"2010","unstructured":"Cheifetz O, , Haley L. Management of secondary lymphedema related to breast cancer. Can Fam Physician, 2010; 56(12):1277\u20131284.","journal-title":"Can Fam Physician"},{"key":"e_1_3_5_5_2","first-page":"5","article-title":"Lymphedema after treatment of breast cancer: A comprehensive review","volume":"4","author":"Ayre K","year":"2019","unstructured":"Ayre K, , Parker C. Lymphedema after treatment of breast cancer: A comprehensive review. J Unexplored Med Data, 2019; 4:5.","journal-title":"J Unexplored Med Data"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2022.01.002"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12939"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0063"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_280471"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31873"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4239"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2019.0035"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0040"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0014"},{"issue":"1","key":"e_1_3_5_15_2","first-page":"2","article-title":"Early diagnosis of lymphedema using multiple frequency bioimpedance","volume":"34","author":"Cornish B","year":"2001","unstructured":"Cornish B, , Chapman M, , Hirst C, et al. Early diagnosis of lymphedema using multiple frequency bioimpedance. Lymphology, 2001; 34(1):2\u201311.","journal-title":"Lymphology"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1191668"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4451-x"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2010.0014"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970205300106"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0082"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.06.1522"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0017"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0085"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614568155"},{"key":"e_1_3_5_25_2","first-page":"PS9","article-title":"Abstract PS9\u201334: Initial experience using the SOZO bio-impedance device over a 2 year surveillance period for identifying subclinical breast cancer related lymphedema (BCRL) in patients attending a multidisciplinary breast clinic","volume":"81","author":"Pfeiffer D","year":"2021","unstructured":"Pfeiffer D, , Lord M, , Lamb C, et al. Abstract PS9\u201334: Initial experience using the SOZO bio-impedance device over a 2 year surveillance period for identifying subclinical breast cancer related lymphedema (BCRL) in patients attending a multidisciplinary breast clinic. AACR, 2021; 81(4_,Suppl):PS9\u201334.","journal-title":"AACR"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06518.x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","unstructured":"Ward LC. Bioelectrical impedance spectrometry for the assessment of lymphoedema: Principles and practice. 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