{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:08:49Z","timestamp":1791954529227,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer-related lymphedema (BCRL) remains a significant postcancer treatment challenge with no definitive cure. Recent supermicrosurgical treatments, such as lymphovenous anastomosis (LVA), have shown promise but lack established objective indicators for outcome evaluation. We investigated the utility of Technetium-99m (Tc-99m) lymphoscintigraphy, an imaging technique providing objective information on lymphatic fluid flow, for assessing LVA surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>A retrospective cohort analysis of patients undergoing LVA for BCRL was conducted. Lymphoscintigraphy images pre- and 1-year postsurgery were compared to determine changes in lymphatic fluid flow of 18 patients based on newly defined parameters \u201cuptake ratio\u201d and \u201cwashout rates.\u201d Statistically significant reduction in the uptake ratio was observed in the forearm at 30 and 60 minutes postinjection phases. In addition, the forearm showed higher washout rate, indicating an improved lymphatic function in the forearm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tc-99m lymphoscintigraphy can provide valuable objective data for evaluating LVA surgical outcomes in BCRL patients. However, site-specific differences in outcomes highlight the need for individualized surgical planning. Further large-scale studies are necessary to validate these preliminary findings and develop a standardized approach for LVA assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2023.0036","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T11:31:31Z","timestamp":1706095891000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the Surgical Outcome of Lymphovenous Anastomosis in Breast Cancer-Related Lymphedema Using Tc-99m Phytate Lymphoscintigraphy: Preliminary Results"],"prefix":"10.1177","volume":"22","author":[{"given":"Yujin","family":"Myung","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseo","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewon","family":"Beom","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitatsu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Lymphedema Center, Kameda Medical Center, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1358","authenticated-orcid":false,"given":"Yoo Sung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-6228","authenticated-orcid":false,"given":"Joseph Kyu-Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947150"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000763"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000189"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586254"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599100"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003362"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009247"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.167.3.3363131"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000375"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25526"},{"issue":"12","key":"e_1_3_5_12_2","first-page":"1362","article-title":"Tc-99m Phytate as an imaging agent for lymph nodes","volume":"19","author":"Gunes NE","year":"1978","unstructured":"Gunes NE, , Ann W. Tc-99m Phytate as an imaging agent for lymph nodes. J Nuclear Med, 1978; 19(12)1362\u20131363.","journal-title":"J Nuclear Med"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1635118"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010245"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-022-06777-z"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2022.0056"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2015.39.6.931"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2017.41.6.1065"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04576-1"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200212000-00004"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0022"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-022-01363-z"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12081346"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1751099"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2021.0092"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2023.0036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2023.0036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2023.0036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:15:05Z","timestamp":1777666505000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2023.0036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4,1]]}},"alternative-id":["10.1089\/lrb.2023.0036"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2023.0036","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]}}}