{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:17:12Z","timestamp":1777922232738,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to determine the course of arm swelling caused by the use of taxanes and to identify valid predictors of persistent swelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      A total of 15 patients with unilateral arm swelling that developed during the course, or within 3 months after termination, of postoperative taxane-based chemotherapy were included in the present study. The patients attended follow-up appointments every 3\u20136 months for 24 months after their initial visit. Their arm circumference was measured at each follow-up appointment, while ultrasonography of the skin and subcutaneous tissues was performed at the 0-, 6-, 12-, and 24-month follow-ups. Of the 15 patients, 12 (80%) saw their taxane-induced arm swelling resolved within a median of 12 months (range, 3\u201329 months) after their final taxane administration. Of the 12 patients whose swelling resolved, 9 did not use compression sleeves; however, their course of resolution did not differ from the other 3 patients who regularly used compression sleeves. In the three patients with persistent swelling, the excess subcutaneous thickness in the medial upper arm (median, 283%) was significantly greater than that in the patients whose swelling resolved (120%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) during their initial visits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Of the 15 patients included in the present study, 80% saw their taxane-induced arm swelling resolve within a median of 12 months after their final taxane administration, independent of the use of compression therapy. Persistent swelling may be predicted during the initial visit based on subcutaneous thickening of the medial upper arm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2023.0040","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:14:48Z","timestamp":1712056488000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Time-Dependent Changes of Extremity Volume and Tissue Alterations in Swollen Arms Caused by Taxanes"],"prefix":"10.1177","volume":"22","author":[{"given":"Kotaro","family":"Suehiro","sequence":"first","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyasu","family":"Morikage","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takasuke","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Ike","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryunosuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kurazumi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.940239"},{"key":"e_1_3_3_3_2","article-title":"Taxane-containing regimens for metastatic breast cancer","volume":"003366","author":"Ghersi D","year":"2015","unstructured":"Ghersi D, , Willson ML, , Chan MM, et al. Taxane-containing regimens for metastatic breast cancer. Cochrane Database Syst Rev, 2015:CD003366; doi: 10.1002\/14651858.CD003366.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2833"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S40601"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0030"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000336480"},{"key":"e_1_3_3_8_2","first-page":"3","article-title":"The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology","volume":"53","author":"Executive Committee of the International Society of L","year":"2020","unstructured":"Executive Committee of the International Society of L. The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology. Lymphology, 2020; 53:3\u201319.","journal-title":"Lymphology"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.04.020"},{"key":"e_1_3_3_10_2","first-page":"56","article-title":"Measuring and representing peripheral oedema and its alterations","volume":"27","author":"Casley-Smith JR","year":"1994","unstructured":"Casley-Smith JR. Measuring and representing peripheral oedema and its alterations. Lymphology, 1994; 27:56\u201370.","journal-title":"Lymphology"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.16-00086"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2004.21458.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.02.012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.071"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10019-012-0033-z"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050312115613351"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3426"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0001-6772.2003.01221.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01052.2003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000386"}],"container-title":["Lymphatic Research and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/lrb.2023.0040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2023.0040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/lrb.2023.0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:15:06Z","timestamp":1777666506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/lrb.2023.0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4,1]]}},"alternative-id":["10.1089\/lrb.2023.0040"],"URL":"https:\/\/doi.org\/10.1089\/lrb.2023.0040","relation":{},"ISSN":["1539-6851","1557-8585"],"issn-type":[{"value":"1539-6851","type":"print"},{"value":"1557-8585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]}}}