{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:05Z","timestamp":1790838365514,"version":"4.1.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>In advanced lymphedema of lower limbs, stage III bandaging under the routinely applied pressure of 40\u201360\u2009mmHg remains largely ineffective. This is caused by skin and subcutaneous tissue stiffness due to fibrosis. Edema fluid accumulates deep in the subcutaneous tissue. Evacuating this fluid requires a high external compression force to overcome the resistance of fibrous tissue. We aimed to investigate the effectiveness of the compression method, with high pressure lasting for 3 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>Twenty-one patients with lower limb lymphedema, stage III, of the postinflammatory type were included. Patients with acute inflammatory symptoms, venous thrombosis, profuse varicose veins, diabetes, and cardiac insufficiency with edema were excluded. A 10-cm-wide rubber bandage was applied to the foot and calf. The interface pressure measured using PicoPress ranged from 58 to 120\u2009mmHg. Skin and deep tissue tonometry, skin water concentration, leg circumference, and drop of interface pressure were measured. Ultrasound examination was done before and after each compression session. The calf circumference decreased by 15.9\u2009\u00b1\u20095.4%, deep tissue stiffness by 58.9\u2009\u00b1\u200918.9%, skin stiffness by 69.6\u2009\u00b1\u200913.5%, and skin water concentration by 43.8\u2009\u00b1\u200911.5%. Interface pressure dropped to 66.3\u2009mmHg (28\u2013110\u2009mmHg); ultrasonography images showed less fluid in the tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>High-pressure 30-minute leg compression can remove excess edema fluid within 3 days and enable adjustment of nonstretch compression stockings. This method is more effective in advanced lymphedema at the beginning of therapy than the standard 30\u201350-mmHg bandaging as it provides an immediate effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/lrb.2023.0064","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T17:01:25Z","timestamp":1712682085000},"page":"153-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["High Pressure 3\u2009\u00d7\u200930 Minute Compression Methods for Advanced Lower Limb Lymphedema Patients"],"prefix":"10.1177","volume":"22","author":[{"given":"Marzanna T.","family":"Zaleska","sequence":"first","affiliation":[{"name":"Clinical and Research Department of Applied Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland."},{"name":"Department of Vascular Surgery, Central Clinical Hospital of the Ministry of Internal Affairs, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia E.","family":"Krzesniak","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Medical Centre of Postgraduate Education, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Lymphatic collecting vessel: New perspectives on mechanisms of contractile regulation and potential lymphatic contractile pathways to target in obesity and metabolic diseases","volume":"13","author":"Lee Y","year":"2022","unstructured":"Lee Y, , Zawieja SD, , Muthuchamy M. 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