{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:20:51Z","timestamp":1777922451452,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Monoclonal Antibodies in Immunodiagnosis & Immunotherapy"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"\n Helicobacter pylori<\/jats:italic>\n infection occurs throughout the world between countries and races. A seroprevalence study of\n H. pylori<\/jats:italic>\n infection in the occurrence of atherosclerosis (\n ASc<\/jats:sc>\n ) has been considered to be the main cause of cardiovascular diseases (CVDs) in part of Iran. From 600 volunteers, 97 serum samples were selected and tested for the presence of\n H. pylori<\/jats:italic>\n infection. Positive and negative\n H. pylori<\/jats:italic>\n infection samples were then selected for\n Chlamydia pneumonia<\/jats:italic>\n and cytomegalovirus infection. Their serum levels for high-sensitive C-reactive protein (hs-CRP) and IL-6 titer were measured using an ELISA test. Prevalence of\n H. pylori<\/jats:italic>\n infection was \u223c68.04% in Karaj. Among the 22 samples of cytokine titration, 4 individuals were\n \n HP\n \u2212<\/jats:sup>\n <\/jats:italic>\n and 18 were\n \n HP\n +<\/jats:sup>\n <\/jats:italic>\n . It was also noticed that 17 samples had normal titration (77.27%) of IL-6 and 3 had a high level of IL-6 (13.63%), 20 people had high hs-CRP titration (90.90%), and 2 were low level hs-CRP (9.1%). Obtained results showed that there is no significant difference between\n HP<\/jats:italic>\n +<\/jats:sup>\n and\n \n HP\n \u2212<\/jats:sup>\n <\/jats:italic>\n infection and IL-6 and hs-CRP titration. Results showed that\n H. pylori<\/jats:italic>\n could not lead to\n ASc<\/jats:sc>\n by increasing the levels of proinflammatory cytokines such as IL-6 and hs-CRP. Further studies are necessary for the detection of mechanism of\n H. pylori<\/jats:italic>\n on\n ASc<\/jats:sc>\n .\n <\/jats:p>","DOI":"10.1089\/mab.2019.0039","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T10:49:41Z","timestamp":1576061381000},"page":"277-281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Seroepidemiology Study of\n Helicobacter pylori<\/i>\n Infection and Its Effect on Cardiovascular Diseases in Karaj, Iran"],"prefix":"10.1177","volume":"38","author":[{"given":"Shadi","family":"Afsharpooyan","sequence":"first","affiliation":[{"name":"Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taher","family":"Mohammadian","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Shahr-e-Qods-Branch, Islamic Azad University, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-117"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.9734\/IJTDH\/2016\/24342"},{"key":"e_1_3_4_6_2","first-page":"654","article-title":"Prevalence and persistence of Chlamydia pneumonia antibodies in healthy laboratory personnel in Finland","volume":"12","author":"Paldanius M","year":"2005","unstructured":"Paldanius M, , Bloigu A, , Alho M, , Leinonen M, , and Saikku P: Prevalence and persistence of Chlamydia pneumonia antibodies in healthy laboratory personnel in Finland. Clin Diagn Lab Immunol, 2005; 12:654\u2013659.","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_3_4_7_2","first-page":"658","article-title":"Detection of Chlamydophila pneumonia (Chlamydia pneumoniae) in endarteroctomy specimens of coronary heart diseases patients","volume":"128","author":"Satpathy G","year":"2008","unstructured":"Satpathy G, , Bhan A, , Sharma A, , and Kar UK: Detection of Chlamydophila pneumonia (Chlamydia pneumoniae) in endarteroctomy specimens of coronary heart diseases patients. Indian J Med Res, 2008; 128:658\u2013662.","journal-title":"Indian J Med Res"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-014-9255-1"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.073"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-8-2-42"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.5.437"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.01.011"},{"key":"e_1_3_4_13_2","first-page":"57","article-title":"Prevalence of Helicobacter pylori infection in Arak, Iran during 2011","volume":"19","author":"Fani A","year":"2014","unstructured":"Fani A, , Rezaei M, , Alizade B, , Mirzajani P, , Shamsikhani S, , Rafeie M, , Malekirad AA, , and Baghi Nejad S: Prevalence of Helicobacter pylori infection in Arak, Iran during 2011. Govaresh, 2014; 19:57\u201362.","journal-title":"Govaresh"},{"key":"e_1_3_4_14_2","first-page":"84","article-title":"Prevalence of Helicobacter pylori infection among children in Rasht, Northern Iran","volume":"1","author":"Mansour-Ghanaei F","year":"2009","unstructured":"Mansour-Ghanaei F, , Yousefi Mashhour M, , Joukar F, , Sedigh M, , Bagher-Zadeh AH, , and Jafarshad R: Prevalence of Helicobacter pylori infection among children in Rasht, Northern Iran. Middle East J Dig Dis, 2009; 1:84\u201388.","journal-title":"Middle East J Dig Dis"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.26719\/2009.15.1.129"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/481365","article-title":"Risk factors and prevalence of Helicobacter pylori infection in persistent high Incidence area of gastric carcinoma in Yangzhong City","volume":"481365","author":"Zhu Y","year":"2014","unstructured":"Zhu Y, , Zhou X, , Wu J, , Su J, , and Zhang G: Risk factors and prevalence of Helicobacter pylori infection in persistent high Incidence area of gastric carcinoma in Yangzhong City. Gastroenterol Res Pract, 2014; 481365:1\u201311.","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_3_4_17_2","first-page":"13","article-title":"Prevalence of Helicobacter pylori infection in children, a population-based cross-sectional study in west Iran","volume":"23","author":"Jafar S","year":"2013","unstructured":"Jafar S, , Jalil A, , Soheila N, , and Sirous S: Prevalence of Helicobacter pylori infection in children, a population-based cross-sectional study in west Iran. Iran J pediatr, 2013; 23:13\u201318.","journal-title":"Iran J pediatr"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1231"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12077"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.12676"},{"key":"e_1_3_4_21_2","first-page":"S58","article-title":"Prevalence of cytomegalovirus antibodies in blood donors at the National Blood Transfusion Centre, Nairobi","volume":"86","author":"Njeru DG","year":"2009","unstructured":"Njeru DG, , Mwanda WO, , Kitonyi GW, , and Njagi EC: Prevalence of cytomegalovirus antibodies in blood donors at the National Blood Transfusion Centre, Nairobi. 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