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The underlying immune response is described with \u201coriginal antigenic sin\u201d (OAS) whereby previous infections influence the response to future virus encounters. We cite evidence for OAS-induced immunopathology in HIV-1 disease. We hypothesize that similar immune abnormalities can occur after infection with SARS-CoV-2. This hypothesis is supported by recent analysis of the antibodies in infected patients demonstrating serological and B cell abnormalities. The concept of symmetrical clonal regulation developed earlier for the immune network illustrates the pathway suggested by our hypothesis and may be helpful to develop strategies avoiding severe coronavirus disease 2019.<\/jats:p>","DOI":"10.1089\/mab.2020.0029","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T14:19:29Z","timestamp":1596809969000},"page":"107-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["A Novel Hypothesis for Original Antigenic Sin in the Severe Disease of SARS-CoV-2 Infection"],"prefix":"10.1177","volume":"39","author":[{"given":"Heinz","family":"Kohler","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Kentucky Emeritus, Lexington, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Nara","sequence":"additional","affiliation":[{"name":"Keytstone Bio, Inc., St. Louis, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01120"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.124.3.331"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01826-10"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90192-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00168-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.3.500"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02015-19"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260618"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189209061779"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1993.tb01734.x"},{"key":"e_1_3_3_12_2","first-page":"344","article-title":"Reduced immunoglobulin kappa\/lambda light chain ratio in perinatally HIV-1-infected children","volume":"5","author":"Saitta M","year":"1994","unstructured":"Saitta M, , Gaido F, , Palomba E, , Cirina P, , Giaccone A, , Ciuti E, , and Tovo P: Reduced immunoglobulin kappa\/lambda light chain ratio in perinatally HIV-1-infected children. 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