{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:21:29Z","timestamp":1777922489955,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Monoclonal Antibodies in Immunodiagnosis &amp; Immunotherapy"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    CD10 is a glycosylated transmembrane protein and is known as a membrane endopeptidase. It is expressed on predifferentiated lymphocyte progenitor, epithelial, stromal, and tumor cells. Therefore, antibodies against CD10 are used for diagnosing follicular lymphoma and solid tumors, including renal carcinomas. In this study, we developed an anti-human CD10 monoclonal antibody, clone C\n                    <jats:sub>10<\/jats:sub>\n                    Mab-31 (IgG\n                    <jats:sub>1<\/jats:sub>\n                    , kappa), which detects CD10 by flow cytometry and shows high affinity for CD10-overexpressed CHO-K1 (CHO\/CD10) cells. Furthermore, the defucosylated mouse IgG\n                    <jats:sub>2a<\/jats:sub>\n                    version of C\n                    <jats:sub>10<\/jats:sub>\n                    Mab-31 (31-mG\n                    <jats:sub>2a<\/jats:sub>\n                    -f) exhibits antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and antitumor activities in mouse xenografts of CHO\/CD10 cells. These results indicate that 31-mG\n                    <jats:sub>2a<\/jats:sub>\n                    -f exerts antitumor effects against CD10-expressing tumors and could be valuable as part of an antibody treatment regimen for them.\n                  <\/jats:p>","DOI":"10.1089\/mab.2021.0048","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T14:49:38Z","timestamp":1650984578000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["A Defucosylated Mouse Anti-CD10 Monoclonal Antibody (31-mG\n                    <sub>2a<\/sub>\n                    -f) Exerts Antitumor Activity in a Mouse Xenograft Model of CD10-Overexpressed Tumors"],"prefix":"10.1177","volume":"41","author":[{"given":"Hiroki","family":"Kawabata","sequence":"first","affiliation":[{"name":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-4474","authenticated-orcid":false,"given":"Tomokazu","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Kawada","sequence":"additional","affiliation":[{"name":"Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika K.","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-8201","authenticated-orcid":false,"given":"Yukinari","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan."},{"name":"Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.118.1.309"},{"key":"e_1_3_3_3_2","first-page":"423","article-title":"Acute lymphocytic leukemia-associated cell membrane antigen","volume":"61","author":"Billing R","year":"1978","unstructured":"Billing R, , Minowada J, , Cline M, , Clark B, , and Lee K: Acute lymphocytic leukemia-associated cell membrane antigen. 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