{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:21:30Z","timestamp":1777922490199,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Monoclonal Antibodies in Immunodiagnosis &amp; Immunotherapy"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    X-linked hypophosphatemia is a genetic condition that leads to fibroblast-growth-factor 23 (FGF23) increase, causing phosphate renal wasting. Since 2018, burosumab, an anti-FGF23 antibody, has been used for this disease with different dosage in children and adults. We report the case of burosumab administration every 2 weeks, as usually done in children. We retrospectively evaluated parathormone (PTH), alkaline phosphatase, serum phosphate, tubular reabsorption of phosphate (TRP), and 25OH vitamin D every 2 weeks in a 29-year-old man with nephrocalcinosis and tertiary hyperparathyroidism who did not respond to standard treatment with burosumab nor to maximum dosage and was treated with burosumab 90\u2009mg every 2 weeks. His serum phosphate and TRP increased with this regimen compared with 4 weeks frequency (respectively 1.74\u2009\u00b1\u20090.26\u2009mg\/dL vs. 2.3\u2009\u00b1\u20090.19\u2009mg\/dL [\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    0.0004] and 71.3%\u2009\u00b1\u20094.8% vs. 83.9%\u2009\u00b1\u20097.9% [\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    0.01]) with decrease in PTH (183\u2009\u00b1\u200924.7\u2009pg\/mL vs. 109\u2009\u00b1\u200912.2\u2009pg\/mL [\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    0.04]). Burosumab may be a good choice in adult patients with X-linked hypophosphatemia; new data are needed regarding the increase in dosage and\/or frequency of administration as usually done in children, to achieve disease control.\n                  <\/jats:p>","DOI":"10.1089\/mab.2022.0026","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T15:20:07Z","timestamp":1687360807000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Burosumab Every 2 Weeks in an Adult with X-Linked Hypophosphatemia: Should We Learn from Children?"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-9231","authenticated-orcid":false,"given":"Alessia","family":"Marcellino","sequence":"first","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bloise","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Pirone","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Brandino","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Gizzone","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Fraternali","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Rome La Sapienza, Roma, Lazio, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dilillo","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Martucci","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariateresa","family":"Sanseviero","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leone Maria","family":"Rita","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Ventriglia","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Maternal-Child Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0152-5"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0447"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0515"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112263252604"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0905-7"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.154049"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72829"},{"key":"e_1_3_6_9_2","first-page":"167","article-title":"Annex I: Internet","author":"Michailidou A","year":"2019","unstructured":"Michailidou A, , Trenz H-J, , de Wilde P. Annex I: Internet. Eur Integr, 2019; 167\u201372.","journal-title":"Eur Integr"},{"key":"e_1_3_6_10_2","unstructured":"FDA. CRYVISTA\/Burosumab prescribing information; 2018; pp. 1\u201317. Available from: www.fda.gov\/medwatch [Last accessed: January1 2023]."},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.570"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.611"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1551"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00189"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00278"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0492-2"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/JME-20-0178"}],"container-title":["Monoclonal Antibodies in Immunodiagnosis &amp; Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mab.2022.0026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mab.2022.0026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mab.2022.0026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:22:02Z","timestamp":1777666922000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mab.2022.0026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1089\/mab.2022.0026"],"URL":"https:\/\/doi.org\/10.1089\/mab.2022.0026","relation":{},"ISSN":["2167-9436","2167-9436"],"issn-type":[{"value":"2167-9436","type":"print"},{"value":"2167-9436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]}}}