{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:40:02Z","timestamp":1770813602830,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    During the last 10 years, a continuous increase in the incidence of \u03b2-lactamase-producing\n                    <jats:italic toggle=\"yes\">Haemophilus influenzae<\/jats:italic>\n                    has been observed; in addition, \u03b2-lactamase-negative ampicillin-resistant strains are better identified and more frequently isolated. During the same period, resistance to tetracyclines and chloramphenicol decreased to a very low level. The incidence of resistant bacteria is highly variable according to the site of infection, patient's age, type of\n                    <jats:italic toggle=\"yes\">Haemophilus<\/jats:italic>\n                    , and country or region, according to local epidemiological factors. Follow-up multicenter studies are needed to monitor the evolution of resistance to these antibiotics and also emergence and spread of resistance to other antibiotics, such as new fluoroquinolones, new \u03b2-lactams, and new macrolides.\n                  <\/jats:p>","DOI":"10.1089\/mdr.1995.1.131","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T17:50:59Z","timestamp":1233251459000},"page":"131-135","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiology of Antibiotic Resistance in\n                    <i>Haemophilus influenzae<\/i>"],"prefix":"10.1177","volume":"1","author":[{"given":"Fred W.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques F.","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.1995.1.131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.1995.1.131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:09:15Z","timestamp":1770746955000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.1995.1.131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1089\/mdr.1995.1.131"],"URL":"https:\/\/doi.org\/10.1089\/mdr.1995.1.131","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}