{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:41:30Z","timestamp":1770788490507,"version":"3.50.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to characterize the molecular basis of \u03b2-lactamase induction in\n                    <jats:italic toggle=\"yes\">Citrobacter diversus<\/jats:italic>\n                    . The chromosomal \u03b2-lactamase encoding region from\n                    <jats:italic toggle=\"yes\">C. diversus<\/jats:italic>\n                    , strain NF85, was cloned and expressed in\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . The cloned region was sequenced and open-reading frames encoding a class A \u03b2-lactamase, designated\n                    <jats:italic toggle=\"yes\">cdiA<\/jats:italic>\n                    , and a putative LysR-type transcriptional regulator protein, divergently transcribed from the \u03b2-lactamase gene and designated\n                    <jats:italic toggle=\"yes\">cdiR<\/jats:italic>\n                    , were identified. The nucleotide sequence of the NF85 cdiA was identical to that of the published\n                    <jats:italic toggle=\"yes\">C. diversus<\/jats:italic>\n                    ULA27\n                    <jats:italic toggle=\"yes\">ampC<\/jats:italic>\n                    sequence. A putative helix-turn-helix DNA-binding motif was located at the N-terminus of CdiR, and homology with enterobacterial AmpR proteins was noted. CdiR was demonstrated to bind to the\n                    <jats:italic toggle=\"yes\">C. diversus cdiAR<\/jats:italic>\n                    intergenic region but not to the\n                    <jats:italic toggle=\"yes\">C. freundii ampCR<\/jats:italic>\n                    intergenic region. A putative CdiR binding motif was identified in the\n                    <jats:italic toggle=\"yes\">cdiAR<\/jats:italic>\n                    intergenic region. The cloned\n                    <jats:italic toggle=\"yes\">cdiAR<\/jats:italic>\n                    region was inducible in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strains SN03 and HfrH. The inducible phenotype was dependent on the\n                    <jats:italic toggle=\"yes\">E. coli ampD<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">ampG<\/jats:italic>\n                    gene products. We conclude that the molecular basis of inducible\n                    <jats:italic toggle=\"yes\">cdiA<\/jats:italic>\n                    expression in\n                    <jats:italic toggle=\"yes\">C. diversus<\/jats:italic>\n                    is similar to that of\n                    <jats:italic toggle=\"yes\">C. freundii ampC<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/mdr.1995.1.285","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T19:43:17Z","timestamp":1233258197000},"page":"285-291","source":"Crossref","is-referenced-by-count":14,"title":["Inducible Expression of the Chromosomal\n                    <i>cdiA<\/i>\n                    from\n                    <i>Citrobacter diversus<\/i>\n                    NF85, Encoding an Ambler Class A \u03b2-Lactamase, Is under Similar Genetic Control to the Chromosomal\n                    <i>ampC<\/i>\n                    , Encoding an Ambler Class C Enzyme, from\n                    <i>Citrobacter freundii<\/i>\n                    OS60"],"prefix":"10.1177","volume":"1","author":[{"given":"Mark E.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,12]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.1995.1.285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.1995.1.285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:09:20Z","timestamp":1770746960000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.1995.1.285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1089\/mdr.1995.1.285"],"URL":"https:\/\/doi.org\/10.1089\/mdr.1995.1.285","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}