{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:24:36Z","timestamp":1791080676451,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>\n                    To determine dissemination and genotype of AmpC \u03b2-lactamases and an extended-spectrum \u03b2-lactamase\namong clinical isolates of Enterobacteriaceae, we performed antibiotic susceptibility testing, pI determination,\ninduction test, plasmid profiles, transconjugation test, enterobacterial repetitive consensus (ERIC)-PCR, and\nDNA sequencing. Among the 51 clinical isolates collected from a university hospital in Korea, six isolates were\nresistant to cephamycins. All six isolates produced a plasmid-encoded AmpC-type \u03b2-lactamase, CMY-10. Five\nstrains also produced one or more other \u03b2-lactamases: SHV-12, an extended-spectrum \u03b2-lactamase (five isolates);\nTEM-1, a class A \u03b2-lactamase (two isolates); and a chromosomal AmpC \u03b2-lactamase (one isolate, a\nstrain of Enterobacter aerogenes, which produced all four of the \u03b2-lactamases that were identified). One of\nsix isolates produced only CMY-10. ERIC-PCR analysis revealed that dissemination of CMY-10 and SHV-12\nwas due to a clonal outbreak of a resistant strain and to the interspecies spread of resistance to cephamycins\nand broad-spectrum \u03b2-lactams in Korea. CMY-10 \u03b2-lactamase genes that are responsible for the resistance\nto cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin, and amoxicillin-clavulanic acid were cloned\nand characterized from six clinical isolates. A sequence identical to the common regions in In6, In7, and a\nnovel integron from pSAL-1 was found upstream from blaCMY-10 gene at nucleotides 1\u201371. A total of 15 nucleotides\n(I-15) or 18 nucleotides (I-18) between position 71 and 72 were inserted into the bla\n                    <jats:sub>CMY-10<\/jats:sub>\n                    gene. The\nbla\n                    <jats:sub>CMY-10<\/jats:sub>\n                    gene might be inserted into a sul1-type complex integron by I-15 or I-18.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2004.10.224","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T03:31:43Z","timestamp":1098502303000},"page":"224-230","source":"Crossref","is-referenced-by-count":17,"title":["Dissemination of Transferable AmpC-type \u03b2-Lactamase (CMY-10) in a Korean Hospital"],"prefix":"10.1177","volume":"10","author":[{"given":"Jung Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biological Science, Myongji University, Kyunggido, 449-728, Republic of Korea."},{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."},{"name":"Microbiology Laboratory, Korea Ocean Research &amp; Development Institute, Seoul 425-600, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Il","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Myongji University, Kyunggido, 449-728, Republic of Korea."},{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Bae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Kosin University College of Medicine, Pusan and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Chul","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Myongji University, Kyunggido, 449-728, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Korea Ocean Research &amp; Development Institute, Seoul 425-600, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Myongji University, Kyunggido, 449-728, Republic of Korea."},{"name":"Bio Technology Innovation Center, Youngdong University, Chungbuk 370-701, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,9]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2004.10.224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2004.10.224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:22:44Z","timestamp":1777666964000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2004.10.224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":0,"aliases":["10.1089\/1076629041939319"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1089\/mdr.2004.10.224"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2004.10.224","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}