{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:08:12Z","timestamp":1792001292562,"version":"4.4.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2005,6]]},"abstract":"\n Prevalence of seven tetracycline resistance (TC\n R<\/jats:sup>\n ) genes\u2014\n tet<\/jats:italic>\n (L),\n tet<\/jats:italic>\n (M),\n tet<\/jats:italic>\n (K),\n tet<\/jats:italic>\n (O),\n tet<\/jats:italic>\n (S),\n tet<\/jats:italic>\n (T), and\n tet<\/jats:italic>\n (U)\u2014\nwhich are known to be distributed to gram-positive cocci was analyzed for 224\n Enterococcus faecalis<\/jats:italic>\n and 46\n Enterococcus faecium<\/jats:italic>\n clinical isolates obtained in a Japanese hospital. Any of the TC\n R<\/jats:sup>\n genes was detected in\n75.9% of all the enterococcal strains. The\n tet<\/jats:italic>\n (M) was detected at highest rates in both\n E. faecalis<\/jats:italic>\n (75.0%) and\n E. faecium<\/jats:italic>\n (69.6%), followed by\n tet<\/jats:italic>\n (L), which was harbored in 6.7% of\n E. faecalis<\/jats:italic>\n isolates and 30.4% of\n E.\nfaecium<\/jats:italic>\n isolates. The\n tet<\/jats:italic>\n (O),\n tet<\/jats:italic>\n (S), and\n tet<\/jats:italic>\n (T) were detected in\n E. faecalis<\/jats:italic>\n at low frequencies mostly associated\nwith\n tet<\/jats:italic>\n (M), while\n tet<\/jats:italic>\n (K) and\n tet<\/jats:italic>\n (U) were not detected. Nucleotide sequences of\n tet<\/jats:italic>\n (S) from\n E. faecalis<\/jats:italic>\n strains\nwere identical to that reported in\n Listeria monocytogenes<\/jats:italic>\n . Sequences of\n tet<\/jats:italic>\n (O) from two\n E. faecalis<\/jats:italic>\n strains were\nalmost identical to each other and also to those from\n Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus\nmutans, Campylobacter jejuni<\/jats:italic>\n , and\n Campylobacter coli<\/jats:italic>\n , although minor sequence divergence was observed.\nThe\n tet<\/jats:italic>\n (T), which had been reported only in\n Streptococcus pyogenes<\/jats:italic>\n , was found in five\n E. faecalis<\/jats:italic>\n strains. Sequence of the enterococcal\n tet<\/jats:italic>\n (T) differed from that of\n S. pyogenes<\/jats:italic>\n by only four nucleotides (four\namino acids) and showed high sequence identity (99.8%, amino acid level). Enterococcal strains with any one\nTC\n R<\/jats:sup>\n gene or those with two TC\n R<\/jats:sup>\n genes showed generally similar MICs of tetracyclines, and no evident difference\nin resistance level was observed.\n <\/jats:p>","DOI":"10.1089\/mdr.2005.11.146","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T09:50:52Z","timestamp":1116841852000},"page":"146-153","source":"Crossref","is-referenced-by-count":28,"title":["Analysis of the Prevalence of Tetracycline Resistance Genes in Clinical Isolates of\n Enterococcus faecalis<\/i>\n and\n Enterococcus faecium<\/i>\n in a Japanese Hospital"],"prefix":"10.1177","volume":"11","author":[{"given":"Yutaka","family":"Nishimoto","sequence":"first","affiliation":[{"name":"Jieitai Hanshin Hospital, Kawanishi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobumichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mahbub","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaho","family":"Ishino","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:22:58Z","timestamp":1777666978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2005.11.146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1089\/mdr.2005.11.146"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2005.11.146","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}