{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:08Z","timestamp":1777922528597,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>\n                    We used multilocus sequencing typing (MLST) to determine the genetic backgrounds of 185 recent penicillinsusceptible\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    isolates with serotypes that most frequently cause invasive disease in\npreschool age children in five Latin American countries\u2014Argentina, Brazil, Colombia, Mexico, and Uruguay.\nMost of the isolates were associated with pneumonia (90\/185), meningitis (74\/185), and bacteremia (17\/185).\nThe collection of strains included seven serotypes\u201414, 6B, 5, 1, 23F\u2014which represent the serotypes of\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    most frequently associated with sterile site infections in children. Also included were strains expressing\nserotypes 7F and 3. Comparison of serotype and multilocus sequence type allowed division of the isolates\ninto two groups: strains expressing serotypes 1, 5, 3, and 7 were represented by a relatively few sequence types\nwhile strains expressing serotypes 6B, 14, and 23F showed great genetic diversity. The genetic diversity of\nserotypes 14, 6B, and 23F may be related to the capacity of these serotypes to colonize the nasopharynx of\nhealthy carriers during which opportunities for diversification through genetic exchanges can occur. The findings\npresent an interesting contrast with the results of an earlier study in which over 80% of invasive penicillin-\nresistant serotype 14 and 23 isolates from the same countries were found to belong to as few as two pandemic\nclones of\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/mdr.2005.11.195","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T13:00:40Z","timestamp":1128430840000},"page":"195-204","source":"Crossref","is-referenced-by-count":23,"title":["Serotypes and Clonal Types of Penicillin-Susceptible\n                    <i>Streptococcus pneumoniae<\/i>\n                    Causing Invasive Disease inChildren in Five Latin American Countries"],"prefix":"10.1177","volume":"11","author":[{"given":"Helena","family":"\u017demli\u010dkov\u00e1","sequence":"first","affiliation":[{"name":"The Rockefeller University, New York, New York."},{"name":"National Institute of Public Health, Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. In\u00eas","family":"Cris\u00f3stomo","sequence":"additional","affiliation":[{"name":"The Rockefeller University, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Brandileone","sequence":"additional","affiliation":[{"name":"Bacteriology Division, Adolfo Lutz Institute, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Camou","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory, Montevideo, Uruguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud, Bogot\u00e1, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Corso","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas, A.N.L.I.S. \"Dr. C. Malbr\u00e1n,\" Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Ech\u00e1niz-Aviles","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud P\u00fablica, Cuernavaca, Morelos, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nika","family":"P\u00e1sztor","sequence":"additional","affiliation":[{"name":"St. Laszlo Hospital for Infectious Diseases, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Tomasz","sequence":"additional","affiliation":[{"name":"The Rockefeller University, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,9]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:02Z","timestamp":1777666982000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2005.11.195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1089\/mdr.2005.11.195"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2005.11.195","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}