{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:07Z","timestamp":1777922527396,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>\n                    The effect of ciprofloxacin and two\n                    <jats:italic toggle=\"yes\">marRAB<\/jats:italic>\n                    inducers on the susceptibility to \u03b2-lactam antibiotics in two AmpC\n\u03b2-lactamase semiconstitutive producer\n                    <jats:italic toggle=\"yes\">Citrobacter freundii<\/jats:italic>\n                    clinical isolates (the DM1 and DM2 strains) was\nstudied. Possible changes in outer membrane protein expression, permeability to cephaloridine, active efflux,\nand hydrolytic activity of \u03b2-lactamase-crude extracts were evaluated under the influence of ciprofloxacin,\nsodium salicylate, and 2,4-dinitrophenol. Results were compared with those of the effect of the same three\nchemicals on a normally \u03b2-lactamase-inducible wild-type\n                    <jats:italic toggle=\"yes\">C. freundii<\/jats:italic>\n                    strain. The three assayed compounds decreased\n\u03b2-lactamase hydrolysis on cephaloridine in both the two clinical isolates as well as in the wild-type\nstrain. However, only the DM1 and DM2 strains showed increased susceptibility to \u03b2-lactams. Sodium salicylate\nand 2,4-dinitrophenol, but not ciprofloxacin, reduced the expression of a 45-kDa outer membrane protein\nin the three studied strains, which was accompanied by a 4- to 20-fold diminution in permeability to\ncephaloridine. In conclusion, two\n                    <jats:italic toggle=\"yes\">marRAB<\/jats:italic>\n                    inducers and ciprofloxacin induced the Mar phenotype and repressed\nAmpC \u03b2-lactamase synthesis in the DM1 and DM2 clinical isolates.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2005.11.225","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T13:00:40Z","timestamp":1128430840000},"page":"225-231","source":"Crossref","is-referenced-by-count":1,"title":["Ciprofloxacin, Salicylate, and 2,4-Dinitrophenol DecreaseProduction of AmpC-Type \u03b2-Lactamase in Two\n                    <i>Citrobacter freundii<\/i>\n                    Clinical Isolates"],"prefix":"10.1177","volume":"11","author":[{"given":"Mar\u00eda M.","family":"Tav\u00edo","sequence":"first","affiliation":[{"name":"Microbiology, Department of Clinical Sciences, School of Medicine, University of Las Palmas de G.C., Dr. Pasteur, 35080-Las Palmas G.C., Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Perilli","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, School of Medicine, University of L'Aquila, L'Aquila, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Vila","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednic, IDIBAPS, School of Medicine, University of Barcelona. 08036 Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pino","family":"Becerro","sequence":"additional","affiliation":[{"name":"Microbiology, Department of Clinical Sciences, School of Medicine, University of Las Palmas de G.C., Dr. Pasteur, 35080-Las Palmas G.C., Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edm","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednic, IDIBAPS, School of Medicine, University of Barcelona. 08036 Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Amicosante","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, School of Medicine, University of L'Aquila, L'Aquila, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T. Jim\u00e9nez","family":"De Anta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednic, IDIBAPS, School of Medicine, University of Barcelona. 08036 Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,9]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:03Z","timestamp":1777666983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2005.11.225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1089\/mdr.2005.11.225"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2005.11.225","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}