{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:10Z","timestamp":1777922530895,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>\n                    The rising prevalence of antibiotic-resistant\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    is a phenomenon observed to different\ndegrees around the world. The present national surveillance study report analyzes a total of 16,756 strains of\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    collected across France in 1999. The overall prevalence of\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    with decreased susceptibility\nto penicillin was 44%, to amoxicillin 26%, and to cefotaxime 17%. The proportion of high-level resistant\nstrains to penicillin (MIC &gt; 1 mg\/L), amoxicillin and cefotaxime (MIC &gt; 2 mg\/L) remained low: 12.3%,\n1.8%, and 0.4% respectively. Prevalence of resistance to other antibiotics was high: 53% to erythromycin,\n41.7% to cotrimoxazole, 31.8% to tetracycline, and 24.6% to chloramphenicol. Prevalence of penicillin-resistant\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    varied according to subject age and specimen source. It was higher in children (52.7%)\nthan in adults (39.8%) and higher in strains isolated from middle ear fluid (63.6%) than from blood cultures\n(41.8%) in children.\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    resistant to other antibiotics were more common in children than in adults,\nalthough figures showed geographical variations. Comparison with a previous study realized in 1997 in the\nsame regions confirms a rising trend in the prevalence of resistant bacteria. Therefore, we conclude that prevalence\nof antibiotic-resistant\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    in 1999 continued to rise in France, although strains with highlevel\nresistance to penicillin remained stable.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2005.11.323","type":"journal-article","created":{"date-parts":[[2005,12,16]],"date-time":"2005-12-16T10:12:03Z","timestamp":1134727923000},"page":"323-329","source":"Crossref","is-referenced-by-count":5,"title":["Antimicrobial Resistance Data on 16,756\n                    <i>Streptococcuspneumoniae<\/i>\n                    Isolates in 1999: A Pan-Regional MulticenterSurveillance Study in France"],"prefix":"10.1177","volume":"11","author":[{"given":"Marie-Claude","family":"Demachy","sequence":"first","affiliation":[{"name":"CH Meaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Vernet-Garnier","sequence":"additional","affiliation":[{"name":"CHU Reims, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Cottin","sequence":"additional","affiliation":[{"name":"CHU Angers, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blandine","family":"Cattier","sequence":"additional","affiliation":[{"name":"CHU Tours, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Chardon","sequence":"additional","affiliation":[{"name":"CH Aix en Provence, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Chomarat","sequence":"additional","affiliation":[{"name":"CHU Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dupont","sequence":"additional","affiliation":[{"name":"CHU Besan\u00e7on, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Fauchere","sequence":"additional","affiliation":[{"name":"CHU Poitiers, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Fosse","sequence":"additional","affiliation":[{"name":"CHU Nice, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Laaberki","sequence":"additional","affiliation":[{"name":"CHU Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Laurans","sequence":"additional","affiliation":[{"name":"CHU Amiens, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Lemozy","sequence":"additional","affiliation":[{"name":"CHU Toulouse, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Maugein","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Murbach","sequence":"additional","affiliation":[{"name":"CHU Strasbourg, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Pechinot","sequence":"additional","affiliation":[{"name":"CHU Dijon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Pierre","family":"Romaszko","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micheline","family":"Roussel-Delvallez","sequence":"additional","affiliation":[{"name":"CHU Lille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Henri","family":"Thoreux","sequence":"additional","affiliation":[{"name":"CHU Saint Brieuc, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Vaucel","sequence":"additional","affiliation":[{"name":"CHU Saint Brieuc, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Vergnaud","sequence":"additional","affiliation":[{"name":"CHU Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Weber","sequence":"additional","affiliation":[{"name":"CHU Nancy, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-C\u00e9cile","family":"Ploy","sequence":"additional","affiliation":[{"name":"CHU Limoges, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,12]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2005.11.323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:11Z","timestamp":1777666991000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2005.11.323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1089\/mdr.2005.11.323"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2005.11.323","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}